SB-435495
National Institutes of Health
Papers overview
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The present study aimed to investigate the effects of lipoprotein-associated phospholipase A2 (Lp-PLA2) on endothelial…
Significance Breakdown of the blood–retinal barrier (BRB) is central to diabetic macular edema (DME). Here, we demonstrate that…
Macrophage activation is, in part, regulated via hydrolysis of oxidised low density lipoproteins by Lipoprotein-Associated…
Diversified anionic phospholipids, phosphatidylserines (PS), externalized to the surface of apoptotic cells are universal…
BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been…
A significant problem in cancer treatment is the development of tumor resistance to chemotherapeutic agents. Acquired drug…
GlaxoSmithKline is investigating a series of substituted pyrimidin-4-ones, including SB-435495, as reversible inhibitors of…