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SB-435495

 
National Institutes of Health

Papers overview

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2017
2017
The present study aimed to investigate the effects of lipoprotein-associated phospholipase A2 (Lp-PLA2) on endothelial… Expand
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2016
2016
Significance Breakdown of the blood–retinal barrier (BRB) is central to diabetic macular edema (DME). Here, we demonstrate that… Expand
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2015
2015
Macrophage activation is, in part, regulated via hydrolysis of oxidised low density lipoproteins by Lipoprotein-Associated… Expand
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2014
2014
Diversified anionic phospholipids, phosphatidylserines (PS), externalized to the surface of apoptotic cells are universal… Expand
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2012
2012
BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been… Expand
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Highly Cited
2003
Highly Cited
2003
Modification of the pyrimidone 5-substituent in clinical candidate SB-435495 has given a series of inhibitors of recombinant… Expand
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2003
2003
A significant problem in cancer treatment is the development of tumor resistance to chemotherapeutic agents. Acquired drug… Expand
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2002
2002
The introduction of a functionalised amido substituent into a series of 1-(biphenylmethylacetamido)-pyrimidones has given a… Expand
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2001
2001
  • M. Booker
  • IDrugs : the investigational drugs journal
  • 2001
  • Corpus ID: 40339235
GlaxoSmithKline is investigating a series of substituted pyrimidin-4-ones, including SB-435495, as reversible inhibitors of… Expand
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