SB-334867

A role for orexin A in mediating the primary and conditioned reinforcing effects of alcohol has been established. It is unclear… (More)

PRINCIPLE The orexin system has been hypothesized to regulate drug-seeking and drug self-administration behaviors, including… (More)

Orexin-expressing neurons are present in hypothalamic nuclei and send projections toward mesolimbic regions such as the nucleus… (More)

Orexin neurons project to a number of brain regions, including onto basal forebrain cholinergic neurons. Basal forebrain… (More)

Orexins (also known as hypocretins) are recently discovered neuropeptides made exclusively in hypothalamic neurons that have been… (More)

1. Orexin-containing neurons have been implicated in feeding, sleep-wake cycles and more recently in drug-seeking behaviour. 2… (More)

Hypocretin-1 and -2 (Hcrt-1 and Hcrt-2), also referred to as orexin-A and -B, are neuropeptides synthesized by a few thousand… (More)

Acute systemic treatment with the selective orexin-1 (OX1R) antagonist SB-334867 reduces food intake in rats, an effect… (More)

Acute systemic treatment with the selective orexin-1 receptor antagonist SB-334867 (30 mg/kg, i.p.) has been reported not only to… (More)

Intracerebroventricular (i.c.v.) administration of the novel hypothalamic neuropeptide orexin-A stimulates food intake in rats… (More)