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SB 258585

Known as: SB-258585, SB258585 
National Institutes of Health

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2 relations

Broader (2)

PiperazinesSulfonamides

Papers overview

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2019
2019
Activation and blockade of dorsal hippocampal Serotonin6 receptors regulate anxiety-like behaviors in a unilateral 6-hydroxydopamine rat model of Parkinson’s disease
ABSTRACT Objectives: This study aimed to investigate the effect of serotonin6 (5-HT6) receptors in the dorsal hippocampus (dHip… 
2016
2016
Activation and blockade of serotonin6 receptors in the dorsal hippocampus enhance T maze and hole-board performance in a unilateral 6-hydroxydopamine rat model of Parkinson's disease
2011
2011
Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission
2011
2011
Serotonergic modulation of extrapyramidal motor disorders in mice and rats: Role of striatal 5-HT3 and 5-HT6 receptors
Highly Cited
2010
Highly Cited
2010
Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.
On the basis of our previously described pharmacophore model for serotonin 5-HT(6) receptor (5-HT(6)R) antagonists, we have… 
Highly Cited
2009
Highly Cited
2009
Role of peripheral and spinal 5-HT6 receptors according to the rat formalin test
Highly Cited
2007
Highly Cited
2007
Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats
The purpose of this study was to investigate the effect of SB-258585, a selective 5-HT6 receptor antagonist, administered… 
Highly Cited
2007
Highly Cited
2007
Increased Expression of 5-HT6 Receptors in the Rat Dorsomedial Striatum Impairs Instrumental Learning
A number of studies have shown that systemic 5-HT6 receptor antagonists can improve learning and memory, but the mechanism for… 
2006
2006
Effects of mutations at conserved TM II residues on ligand binding and activation of mouse 5-HT6 receptor.
2000
2000
Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissue.
SB-258585 (4-Iodo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzen esulphonamide) is a high affinity ligand at 5-HT(6… 
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