Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats

@article{Wesoowska2007AnxiolyticlikeAA,
  title={Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats},
  author={Anna Wesołowska and Agnieszka Nikiforuk and Katarzyna Stachowicz},
  journal={Behavioural Pharmacology},
  year={2007},
  volume={18},
  pages={439-446}
}
The purpose of this study was to investigate the effect of SB-258585, a selective 5-HT6 receptor antagonist, administered intrahippocampally to rats, in the conflict drinking and forced swim tests, that is models used for evaluating anxiolytic-like and antidepressant-like activity, respectively. Diazepam and imipramine were used as reference drugs. SB-258585 at a dose of 1 μg (but not 0.3 and 3 μg) showed an anticonflict effect that was weaker than that of diazepam (40 μg). SB-258585 at a dose… Expand
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