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SB 220025

Known as: SB-220025, SB220025 
National Institutes of Health

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Broader (2)

ImidazolesPyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger…
The placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2; encoded by the HSD11B2 gene) has emerged as a key player… 
2009
2009
Inhibition of p38-MAPK potentiates cisplatin-induced apoptosis via GSH depletion and increases intracellular drug accumulation in growth-arrested kidney tubular epithelial cells.
We were interested in analyzing the regulation by mitogen-activated protein kinases (MAPKs) of cisplatin-provoked toxicity in… 
2006
2006
Pharmacologic inhibitors of extracellular signal‐regulated kinase (ERKs) and c‐Jun NH2‐terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia Cells to arsenic…
Treatment with 1–4 µM As2O3 slightly induced apoptosis in U‐937 human promonocitic leukemia cells. This effect was potentiated by… 
Highly Cited
2005
Highly Cited
2005
p38 mitogen‐activated protein kinase (MAPK) first regulates filamentous actin at the 8–16‐cell stage during preimplantation development
Background information. The MAPK (mitogen‐activated protein kinase) superfamily of proteins consists of four separate signalling… 
2005
2005
Mitogen-activated protein kinase (MAPK) blockade of bovine preimplantation embryogenesis requires inhibition of both p38 and extracellular signal-regulated kinase (ERK) pathways.
Blastocyst formation, as a critical period during development, is an effective indicator of embryonic health and reproductive… 
2005
2005
Activation of p38MAPK signaling cascade in a VSMC injury model: role of p38MAPK inhibitors in limiting VSMC proliferation.
Highly Cited
2004
Highly Cited
2004
p38 MAPK signaling during murine preimplantation development.
Highly Cited
2003
Highly Cited
2003
A role for COX-2 and p38 mitogen activated protein kinase in long-term depression in the rat dentate gyrus in vitro
Highly Cited
2003
Highly Cited
2003
Comparison of antiproliferative effects of experimental and established antipsoriatic drugs on human kerationocytes, using a simple 96-well-plate assay
SummaryPharmacological treatments for psoriasis are generally based on antiproliferative, anti-inflammatory, or differentiation… 
Highly Cited
2002
Highly Cited
2002
A novel regulatory mechanism of the mitochondrial Ca2+ uniporter revealed by the p38 mitogen‐activated protein kinase inhibitor sb202190
It is widely acknowledged that mitochondrial Ca2+ uptake modulates the cytosolic [Ca2+] ([Ca2+]c) acting as a transient Ca2… 
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