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SB 1518

Known as: SB-1518, SB1518 
 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Pacritinib (SB1518) is a Janus kinase 2 (JAK2), JAK2(V617F), and Fms-like tyrosine kinase 3 inhibitor that does not inhibit JAK1… Expand
Highly Cited
2012
Highly Cited
2012
PURPOSE The Janus kinase 2/signal transducers and activators of transcription (JAK2/STAT) pathway plays an important role in the… Expand
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Highly Cited
2012
Highly Cited
2012
Acute myeloid leukemia (AML) is currently treated with aggressive chemotherapy that is not well tolerated in many elderly… Expand
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2012
2012
Herein, we describe the synthesis and SAR of a series of small molecule macrocycles that selectively inhibit JAK2 kinase within… Expand
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Highly Cited
2011
Highly Cited
2011
SB1518 is an innovative pyrimidine-based macrocycle that shows a unique kinase profile with selective inhibition of Janus Kinase… Expand
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Highly Cited
2011
Highly Cited
2011
Discovery of the activating mutation V617F in Janus Kinase 2 (JAK2(V617F)), a tyrosine kinase critically involved in receptor… Expand
Highly Cited
2011
Highly Cited
2011
Abstract 282 Background: The JAK2V617F mutation has been linked to the pathogenesis of myeloproliferative neoplasia. Pacritinib… Expand
Highly Cited
2011
Highly Cited
2011
FMS-like tyrosine kinase 3 (FLT3) is the most commonly mutated gene found in acute myeloid leukemia (AML) patients and its… Expand
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2011
2011
6515 Background: The JAK2V617F mutant enzyme has been linked to the pathogenesis of myeloproliferative neoplasms. SB1518 is a… Expand
Highly Cited
2009
Highly Cited
2009
Abstract 3905 Poster Board III-841 Mutation of Janus Associated Kinase 2 (JAK2) at amino acid 617 and the resulting… Expand