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SB 1518
Known as:
SB-1518
, SB1518
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
pacritinib
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis.
R. Komrokji
,
J. Seymour
,
+10 authors
R. Mesa
Blood
2015
Corpus ID: 20843763
Pacritinib (SB1518) is a Janus kinase 2 (JAK2), JAK2(V617F), and Fms-like tyrosine kinase 3 inhibitor that does not inhibit JAK1…
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Review
2013
Review
2013
Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application
M. Furqan
,
N. Mukhi
,
Byung Lee
,
Delong Liu
Biomarker Research
2013
Corpus ID: 16414020
JAK-STAT (Janus associated kinase-signal transducer and activator of transcription) pathway plays a critical role in transduction…
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Review
2013
Review
2013
Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib
E. Derenzini
,
A. Younes
Expert Opinion on Investigational Drugs
2013
Corpus ID: 25542955
Introduction: The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway mediates signaling by…
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Highly Cited
2012
Highly Cited
2012
Phase I study of a novel oral Janus kinase 2 inhibitor, SB1518, in patients with relapsed lymphoma: evidence of clinical and biologic activity in multiple lymphoma subtypes.
A. Younes
,
J. Romaguera
,
+12 authors
Joy Zhu
Journal of Clinical Oncology
2012
Corpus ID: 207032623
PURPOSE The Janus kinase 2/signal transducers and activators of transcription (JAK2/STAT) pathway plays an important role in the…
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Highly Cited
2012
Highly Cited
2012
The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML
V. Novotny‐Diermayr
,
S. Hart
,
+7 authors
J. Wood
Blood Cancer Journal
2012
Corpus ID: 2220060
Acute myeloid leukemia (AML) is currently treated with aggressive chemotherapy that is not well tolerated in many elderly…
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Highly Cited
2011
Highly Cited
2011
Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus…
A. William
,
Angeline Lee
,
+16 authors
B. Dymock
Journal of Medicinal Chemistry
2011
Corpus ID: 28808475
Discovery of the activating mutation V617F in Janus Kinase 2 (JAK2(V617F)), a tyrosine kinase critically involved in receptor…
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Highly Cited
2011
Highly Cited
2011
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
S. Hart
,
K. Goh
,
+15 authors
J. Wood
Leukemia
2011
Corpus ID: 11194786
SB1518 is an innovative pyrimidine-based macrocycle that shows a unique kinase profile with selective inhibition of Janus Kinase…
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Highly Cited
2011
Highly Cited
2011
Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia
S. Hart
,
K. Goh
,
+9 authors
J. Wood
Blood Cancer Journal
2011
Corpus ID: 351485
FMS-like tyrosine kinase 3 (FLT3) is the most commonly mutated gene found in acute myeloid leukemia (AML) patients and its…
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Highly Cited
2011
Highly Cited
2011
Results of a Phase 2 Study of Pacritinib (SB1518), a Novel Oral JAK2 Inhibitor, In Patients with Primary, Post-Polycythemia Vera, and Post-Essential Thrombocythemia Myelofibrosis
R. Komrokji
,
M. Wadleigh
,
+4 authors
R. Mesa
2011
Corpus ID: 78262337
Abstract 282 Background: The JAK2V617F mutation has been linked to the pathogenesis of myeloproliferative neoplasia. Pacritinib…
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Highly Cited
2009
Highly Cited
2009
Phase I Dose-Escalation Trial of SB1518, a Novel JAK2/FLT3 Inhibitor, in Acute and Chronic Myeloid Diseases, Including Primary or Post-Essential Thrombocythemia/ Polycythemia Vera Myelofibrosis.
S. Verstovsek
,
O. Odenike
,
+9 authors
H. Deeg
2009
Corpus ID: 78651307
Abstract 3905 Poster Board III-841 Mutation of Janus Associated Kinase 2 (JAK2) at amino acid 617 and the resulting…
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