Phase II study of SB1518, an orally available novel JAK2 inhibitor, in patients with myelofibrosis.

@article{Deeg2011PhaseIS,
  title={Phase II study of SB1518, an orally available novel JAK2 inhibitor, in patients with myelofibrosis.},
  author={H. Joachim Deeg and O. Odenike and Bart L. Scott and Zeev E Estrov and Jorge E. Cortes and Deborah A. Thomas and H Zhu and Hagop M. Kantarjian and Srdan Verstovsek},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 15\_suppl},
  pages={6515}
}
  • H. Deeg, O. Odenike, S. Verstovsek
  • Published 20 May 2011
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
6515 Background: The JAK2V617F mutant enzyme has been linked to the pathogenesis of myeloproliferative neoplasms. SB1518 is a potent inhibitor of JAK2 and its JAK2V617F mutant. In Phase 1 study, myelofibrosis (MF) patients treated with SB1518 achieved steady-state plasma levels above the IC50 for JAK2 at all doses (100-600 mg/d). Target inhibition, measured by phosphorylation of STAT3, STAT5, and JAK proteins in PBMCs and whole blood, was also shown at all doses. 400 mg/d was chosen for Phase 2… 
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