SAR245409

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2014-2018
02420142018

Papers overview

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2016
2016
The phosphoinositide 3-kinases (PI3Ks) are critical components of the B-cell receptor (BCR) pathway and have an important role in… (More)
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2016
2016
The aim of this study was to clarify the synergistic effects of dual inhibition of the PI3K/mTOR and MAPK pathways in ovarian… (More)
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2015
2015
The maximum tolerated dose of SAR245409 (voxtalisib), a pan-class I phosphoinositide 3-kinase (PI3K) and mammalian target of… (More)
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2015
2015
BACKGROUND This phase I study aimed to evaluate safety, maximum tolerated dose, pharmacokinetics, pharmacodynamics, and… (More)
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2015
2015
OBJECTIVE We aimed to clarify whether dual inhibition of PI3K/MAPK and MAPK pathways synergistically suppresses cell growth in… (More)
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2015
2015
Mechanisms leading to inhibitory effects of an anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) and PI3K/Akt/mTOR… (More)
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2015
2015
This phase I/II dose-escalation study evaluated the efficacy, safety, and pharmacokinetics of pilaralisib (SAR245408), a pan… (More)
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2014
2014
PURPOSE This phase I, first-in-human study evaluated the safety, maximum-tolerated dose (MTD), pharmacokinetics, pharmacodynamics… (More)
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2014
2014
Activation of the PI3K (phosphoinositide 3-kinase) pathway is a frequent occurrence in human tumors and is thought to promote… (More)
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2014
2014
INTRODUCTION The primary objectives of this phase I study were to evaluate the safety and maximum tolerated dose (MTD) of… (More)
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