SAR245409
National Institutes of Health
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Triple-negative breast cancer (TNBC) is a major cause of death among breast cancer patients that results from intrinsic and…
Mechanisms leading to inhibitory effects of an anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) and PI3K/Akt/mTOR…
ABSTRACT Aim: To investigate safety and efficacy in four expansion cohorts treated with the combination of PIM and SAR. Methods…
CLL cells are highly dependent on B- cell receptor (BCR) signaling and on stimuli from the microenvironment for survival and…
2530 Background: PI3K/mTOR and MAPK signaling pathways are often deregulated in tumors. Simultaneous inhibition of these pathways…
Background: The PI3K/mTOR and MAPK signaling pathways are frequently aberrated in tumors and interact to promote growth. This…
Background Dysregulation of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway signaling has been…
Background: Upregulation of PI3K activity is a common molecular mechanism involved in resistance to AIs. S08 is a potent, orally…
3030 Background: XL765 is a potent and selective inhibitor of class I PI3K isoforms, TORC1, and TORC2. XL765 has shown dose…
3015 Background: The PI3K pathway is frequently dysregulated in cancer cells and has been implicated as a mechanism of resistance…