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SAR245409

 
National Institutes of Health

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2016
2016
The current standard of care for glioblastoma (GBM) is surgical resection, radiotherapy, and treatment with temozolomide (TMZ… Expand
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2015
2015
OBJECTIVE We aimed to clarify whether dual inhibition of PI3K/MAPK and MAPK pathways synergistically suppresses cell growth in… Expand
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2015
2015
Abstract The maximum tolerated dose of SAR245409 (voxtalisib), a pan-class I phosphoinositide 3-kinase (PI3K) and mammalian… Expand
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2015
2015
BACKGROUND This phase I study aimed to evaluate safety, maximum tolerated dose, pharmacokinetics, pharmacodynamics, and… Expand
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2015
2015
Deregulation of phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling… Expand
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Highly Cited
2014
Highly Cited
2014
PURPOSE This phase I, first-in-human study evaluated the safety, maximum-tolerated dose (MTD), pharmacokinetics, pharmacodynamics… Expand
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2014
2014
Activation of the PI3K (phosphoinositide 3-kinase) pathway is a frequent occurrence in human tumors and is thought to promote… Expand
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2014
2014
INTRODUCTION The primary objectives of this phase I study were to evaluate the safety and maximum tolerated dose (MTD) of… Expand
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2010
2010
3030 Background: XL765 is a potent and selective inhibitor of class I PI3K isoforms, TORC1, and TORC2. XL765 has shown dose… Expand
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2010
2010
3015 Background: The PI3K pathway is frequently dysregulated in cancer cells and has been implicated as a mechanism of resistance… Expand
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