SAICAR

Known as: 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole, 5-amino-4-imidazole-N-succinocarboxamide ribonucleotide, succinyl-AICAR 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2017
02419682017

Papers overview

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2014
2014
Abnormal metabolism and sustained proliferation are hallmarks of cancer. Pyruvate kinase M2 (PKM2) is a metabolic enzyme that… (More)
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2013
2013
The enzyme SAICAR synthetase ligates aspartate with CAIR (5'-phosphoribosyl-4-carboxy-5-aminoimidazole) forming SAICAR (5-amino-4… (More)
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2013
2013
Pyruvate kinase isoform M2 (PKM2) activity is subject to complex allosteric regulation. Recently, serine and SAICAR… (More)
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2012
2012
Pyruvate kinase isoform M2 (PKM2) plays an important role in the growth and metabolic reprogramming of cancer cells in stress… (More)
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2006
2006
As a part of a structural genomics program, the 2.2 angstroms resolution crystal structure of the PurC gene product from… (More)
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2001
2001
In Saccharomyces cerevisiae, AMP biosynthesis genes (ADE genes) are transcriptionally activated in the absence of extracellular… (More)
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1999
1999
Formation of 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) in the purine pathway in most prokaryotes requires ATP, HCO3… (More)
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1998
1998
BACKGROUND The biosynthesis of key metabolic components is of major interest to biologists. Studies of de novo purine synthesis… (More)
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1994
1994
A comparative investigation of the substrate requirements for the enzyme 5-aminoimidazole ribonucleotide (AIR) carboxylase from E… (More)
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1980
1980
Two complementary methods have been devised for measuring the activity of 5-amino-4-imidazole-N-succinocarboxamide ribonucleotide… (More)
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