S Phase Cell Cycle Checkpoints

Known as: Checkpoints, S Phase, S-phase checkpoint, S Phase Cell Cycle Checkpoint 
Cell regulatory signaling system that controls progression through S PHASE and stabilizes the replication forks during conditions that could affect… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
0102019952017

Related topics

Related topics

3 relations
aspects of radiation effectsphysiological aspects

Narrower (1)

mitotic DNA replication checkpoint

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
S Phase Cell Cycle Checkpoints
physiological aspects
mitotic DNA replication checkpoint
aspects of radiation effects

Papers overview

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Highly Cited
2012
Highly Cited
2012
Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases.
The S phase checkpoint pathway preserves genome stability by protecting defective DNA replication forks, but the underlying… (More)
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Highly Cited
2012
Highly Cited
2012
The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing
When replication forks stall at damaged bases or upon nucleotide depletion, the intra-S phase checkpoint ensures they are… (More)
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Highly Cited
2008
Highly Cited
2008
Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint.
Yeast Mrc1, ortholog of metazoan Claspin, is both a central component of normal DNA replication forks and a mediator of the S… (More)
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Highly Cited
2003
Highly Cited
2003
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
Chk1 kinase coordinates cell cycle progression and preserves genome integrity. Here, we show that chemical or genetic ablation of… (More)
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2003
2003
Physiological electric fields control the G1/S phase cell cycle checkpoint to inhibit endothelial cell proliferation.
Vascular endothelial cell (VEC) proliferation is a key event in angiogenesis and is tightly regulated. Electric potential… (More)
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Highly Cited
2002
Highly Cited
2002
The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways
To preserve genetic integrity, mammalian cells exposed to ionizing radiation activate the ATM kinase, which initiates a complex… (More)
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Highly Cited
2001
Highly Cited
2001
Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae
Cancer cells show increased genome rearrangements, although it is unclear what defects cause these rearrangements. Mutations in… (More)
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Highly Cited
2001
Highly Cited
2001
The yeast Xrs2 complex functions in S phase checkpoint regulation.
The Nbs1 complex is an evolutionarily conserved multisubunit nuclease composed of the Mre11, Rad50, and Nbs1 proteins… (More)
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Highly Cited
1995
Highly Cited
1995
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint.
Inhibition of DNA synthesis induces transcription of DNA damage-inducible genes and prevents mitotic entry through the action of… (More)
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Highly Cited
1995
Highly Cited
1995
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
Commitment of mammalian cells to enter S phase enables the transcription factor E2F-1 to activate certain genes whose products… (More)
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