Biology of incretins: GLP-1 and GIP.
- L. Baggio, D. Drucker
- Biology, MedicineGastroenterology
- 1 May 2007
This review focuses on the mechanisms regulating the synthesis, secretion, biological actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic polypeptide (GIP)…
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
- D. Drucker, M. Nauck
- Medicine, BiologyThe Lancet
- 11 November 2006
The biology of incretin hormones.
- D. Drucker
- Medicine, BiologyCell Metabolism
- 1 March 2006
Pharmacology, physiology, and mechanisms of incretin hormone action.
- Jonathan E. Campbell, D. Drucker
- Biology, MedicineCell Metabolism
- 4 June 2013
Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways
- Kiwon Ban, M. H. Noyan-Ashraf, J. Hoefer, S. Bolz, D. Drucker, M. Husain
- Biology, MedicineCirculation
- 6 May 2008
It is shown that endothelium and cardiac and vascular myocytes express a functional GLP-1R as GLp-1 administration increased glucose uptake, cAMP and cGMP release, left ventricular developed pressure, and coronary flow in isolated mouse hearts, and this data suggest that the extent to which GLP -1 is metabolized to GLP(9-36) may have functional implications in the cardiovascular system.
Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study
- D. Drucker, J. Buse, L. Porter
- MedicineThe Lancet
- 4 October 2008
Incretin-based therapies for type 2 diabetes mellitus
- J. Lovshin, D. Drucker
- Biology, MedicineNature Reviews Endocrinology
- 1 May 2009
This Review highlights the current understanding of the mechanisms of action of incretin-based drugs, with an emphasis on the emerging clinical profile of new agents.
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
- M. Claussnitzer, S. Dankel, Manolis Kellis
- Biology, MedicineNew England Journal of Medicine
- 2 September 2015
The data indicate that the FTO allele associated with obesity represses mitochondrial thermogenesis in adipocyte precursor cells in a tissue-autonomous manner, and points to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-ob obesity effects.
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
Systemic administration of [Ser(2)]exendin(1–9) in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons and represents a promising new target for both cognitive-enhancing and neuroprotective agents.
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
- H. Ellingsgaard, Irina Hauselmann, M. Donath
- Medicine, BiologyNature Network Boston
- 1 November 2011
Interleukin-6 mediates crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand and suggests that drugs modulating this loop may be useful in type 2 diabetes.
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