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S 3226

Known as: S-3226, S3226 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers
Hepatocyte growth factor (HGF) is found in tumor microenvironments, and interaction with its tyrosine kinase receptor Met… 
Highly Cited
2009
Highly Cited
2009
Na+/H+ Exchangers and RhoA Regulate Acidic Extracellular pH‐Induced Lysosome Trafficking in Prostate Cancer Cells
Acidic extracellular pH (pHe) is a common feature of the tumor microenvironment and has been implicated in tumor invasion through… 
Highly Cited
2008
Highly Cited
2008
Gastrointestinal Distribution and Kinetic Characterization of the Sodium-Hydrogen Exchanger Isoform 8 (NHE8)
NHE8 is a newly identified NHE isoform expressed in rat intestine. To date, the kinetic characteristics and the intestinal… 
Highly Cited
2006
Highly Cited
2006
Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa
The duodenum is the site of mixing of massive amounts of gastric H+ with secreted HCO3−, generating CO2 and H2O accompanied by… 
Highly Cited
2005
Highly Cited
2005
ClC-5: role in endocytosis in the proximal tubule.
The proper functioning of the Cl(-) channel, ClC-5, is essential for the uptake of low molecular mass proteins through receptor… 
Highly Cited
2003
Highly Cited
2003
Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon.
Bicarbonate and butyrate stimulate electroneutral Na absorption via apical membrane Na-H exchange (NHE) in rat distal colon. cAMP… 
Highly Cited
2002
Highly Cited
2002
Na(+)/H(+) exchanger 3 is in large complexes in the center of the apical surface of proximal tubule-derived OK cells.
Cell biological approaches were used to examine the location and function of the brush border (BB) Na(+)/H(+) exchanger NHE3 in… 
Highly Cited
2001
Highly Cited
2001
Expression of Multiple Na+/H+ Exchanger Isoforms in Cultured Epithelial Cells from Rat Efferent Duct and Cauda Epididymidis1
Abstract Although earlier work has pointed to the presence of Na+/H+ exchangers (NHEs) in the rat epididymis, little is known… 
Highly Cited
2000
Highly Cited
2000
Role of Na(+)/H(+) exchanger NHE3 in nephron function: micropuncture studies with S3226, an inhibitor of NHE3.
Na(+)/H(+) exchanger NHE3 is expressed in the luminal membrane of proximal tubule and thin and thick ascending limb of Henle's… 
Highly Cited
1999
Highly Cited
1999
Selective inhibition of the Na+/H+ exchanger type 3 activates CO2/H+-sensitive medullary neurones
Abstract Hypercapnia as well as lowered intracellular pH (pHi) increase the bioelectric activity of CO2/H+-sensitive neurones… 
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