ClC-5: role in endocytosis in the proximal tubule.

@article{Wang2005ClC5RI,
  title={ClC-5: role in endocytosis in the proximal tubule.},
  author={Yinghong Wang and Hui Cai and Liudmila Cebotaru and Deanne H. Hryciw and Edward J. Weinman and Mark Donowitz and Sandra E. Guggino and William B Guggino},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={289 4},
  pages={
          F850-62
        }
}
The proper functioning of the Cl(-) channel, ClC-5, is essential for the uptake of low molecular mass proteins through receptor-mediated endocytosis in the proximal tubule. Dent's disease patients with mutant ClC-5 channels and ClC-5 knockout (KO) mice both have low molecular mass proteinuria. To further understand the function of ClC-5, endocytosis was studied in LLC-PK(1) cells and primary cultures of proximal tubule cells from wild-type (WT) and ClC-5 KO kidneys. Endocytosis in the proximal… CONTINUE READING

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NHE3 Na /H exchanger supports proximal tubular pro F861 CLC-5 AND DENT’S DISEASE AJP-Renal Physiol

  • M Gekle, K Volker, S Mildenberger, R Freudinger, GE Shull, M. Wiemann
  • Am J Physiol Renal Physiol 287: F469–F473,
  • 2005
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