ClC-5: role in endocytosis in the proximal tubule.

@article{Wang2005ClC5RI,
  title={ClC-5: role in endocytosis in the proximal tubule.},
  author={Y. Wang and Hui Cai and L. Cebotaru and D. Hryciw and E. Weinman and M. Donowitz and S. E. Guggino and W. Guggino},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={289 4},
  pages={
          F850-62
        }
}
  • Y. Wang, Hui Cai, +5 authors W. Guggino
  • Published 2005
  • Medicine, Biology, Chemistry
  • American journal of physiology. Renal physiology
  • The proper functioning of the Cl(-) channel, ClC-5, is essential for the uptake of low molecular mass proteins through receptor-mediated endocytosis in the proximal tubule. Dent's disease patients with mutant ClC-5 channels and ClC-5 knockout (KO) mice both have low molecular mass proteinuria. To further understand the function of ClC-5, endocytosis was studied in LLC-PK(1) cells and primary cultures of proximal tubule cells from wild-type (WT) and ClC-5 KO kidneys. Endocytosis in the proximal… CONTINUE READING
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