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S-013420

National Institutes of Health

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EDP 420

Papers overview

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2015
2015
In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains.
OBJECTIVES New antimicrobials are essential to prevent gonorrhoea becoming an untreatable infection. Herein, the in vitro… 
2014
2014
The wobbly status of ketolides: where do we stand?
Ketolides are erythromycin A derivatives with a keto group replacing the cladinose sugar and an aryl-alkyl group attached to the… 
2014
2014
Pharmacodynamic profiling of modithromycin: assessment in a pneumococcal murine pneumonia model.
2010
2010
In Vitro Pharmacokinetic and Pharmacodynamic Evaluation of S-013420 against Haemophilus influenzae and Streptococcus pneumoniae
ABSTRACT The pharmacokinetic (PK)/pharmacodynamic (PD) parameters and the antibacterial activity of S-013420, a novel bicyclolide… 
2010
2010
In vitro antibacterial activities of S-013420, a novel bicyclolide, against respiratory tract pathogens.
OBJECTIVES The in vitro activity of S-013420, a novel bicyclolide, was investigated. METHODS All test strains for this study… 
2009
2009
Intrapulmonary Pharmacokinetics of S-013420, a Novel Bicyclolide Antibacterial, in Healthy Japanese Subjects
ABSTRACT S-013420 (EDP-420) is a novel bicyclolide (bridged bicyclic macrolide) antibacterial currently under development for the… 
2009
2009
Pharmacokinetics of EDP-420 after Ascending Single Oral Doses in Healthy Adult Volunteers
ABSTRACT EDP-420 (EP-013420, S-013420) is a first-in-class bicyclolide (bridged bicyclic macrolide) currently in clinical… 
2009
2009
Pharmacokinetics of EDP-420 after Multiple Oral Doses in Healthy Adult Volunteers and in a Bioequivalence Study
ABSTRACT EDP-420 (also known as EP-013420, or S-013420) is a first-in-class bridged bicyclolide currently in clinical development… 
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