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Recombinant Glial Cell-Line Derived Neurotrophic Factor

Known as: GDNF, Glial Cell-Line Derived Neurotrophic Factor 
A recombinant therapeutic agent which is chemically identical to or similar to endogenous glial cell line-derived neurotrophic factor (GDNF). GDNF is… 
National Institutes of Health

Related topics

Related topics

4 relations
GDNF geneGDNF protein, human

Broader (2)

Glial Cell Line-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic Factors

Papers overview

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Review
2008
Review
2008
GDNF therapy for Parkinson’s disease
With an increase in the aging population, the incidence of Parkinson’s disease (PD), a disabling neurodegenerative disorder… 
Review
2007
Review
2007
GDNF family receptor complexes are emerging drug targets.
Highly Cited
2006
Highly Cited
2006
Neurotensin polyplex as an efficient carrier for delivering the human GDNF gene into nigral dopamine neurons of hemiparkinsonian rats.
Review
2003
Review
2003
Novel functions and signalling pathways for GDNF
Glial-cell-line-derived neurotrophic factor (GDNF) was originally identified as a survival factor for midbrain dopaminergic… 
Highly Cited
2002
Highly Cited
2002
Persephin-Overexpressing Neural Stem Cells Regulate the Function of Nigral Dopaminergic Neurons and Prevent Their Degeneration in a Model of Parkinson's Disease
Persephin (PSP) is a neurotrophic factor of the GDNF family that has been found to promote the survival of multiple populations… 
Highly Cited
2002
Highly Cited
2002
Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector
We used a recombinant lentiviral vector (rLV) for gene delivery of GDNF to the striatum, and assessed its neuroprotective effects… 
Highly Cited
1999
Highly Cited
1999
GDNF improves dopamine function in the substantia nigra but not the putamen of unilateral MPTP-lesioned rhesus monkeys
Highly Cited
1997
Highly Cited
1997
Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson…
Glial-cell-line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for adult nigral dopamine neurons in vivo… 
Highly Cited
1995
Highly Cited
1995
Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro
Growth factors have been shown to be involved in the regulation of division and differentiation of neuroepithelial cells. In the… 
Highly Cited
1993
Highly Cited
1993
Regional and Cell-Specific Expression of GDNF in Rat Brain
The survival of ventral mesencephalic substantia nigra (SN) dopamine neurons, which degenerate in Parkinson's disease, is… 
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