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Recombinant EphB4-HSA Fusion Protein

Known as: sEphB4-HSA 
A recombinant fusion protein composed of the full-length extracellular domain (soluble) of human receptor tyrosine kinase ephrin type-B receptor 4… Expand
National Institutes of Health

Related topics

Related topics

1 relation
NCIt Antineoplastic Agent Terminology

Papers overview

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2018
2018
A first-in-human phase I study of sEphB4-HSA (sEphB4) with expansion in hepatocellular (HCC) and cholangiocarcinoma (CCA).
285Background: EphrinB4, a receptor kinase, is associated with stage and survival in epithelial cancers. sEphB4 is a fusion… Expand
2016
2016
Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas
Members of the Eph family of receptor tyrosine kinases have been implicated in a wide array of human cancers. The EphB4 receptor… Expand
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2016
2016
A first-in-human phase I study of sEphB4-HSA in patients with advanced solid tumors with expansion at the maximum tolerated dose (MTD) or recommended phase II dose (RP2D)
2016
2016
Circulating tumor cell analysis in a first-in-human phase I study of sEphB4-HSA, an inhibitor of EphrinB2-EphB4 signaling
2014
2014
The Differential Expression of EphB2 and EphB4 Receptor Kinases in Normal Bladder and in Transitional Cell Carcinoma of the Bladder
Effective treatment of transitional cell carcinoma (TCC) of the bladder requires early diagnosis. Identifying novel molecular… Expand
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2014
2014
In vivo efficacy of sEphB4-HSA combined with Bevacizumab.
2013
2013
EphB4 as a therapeutic target in mesothelioma
BackgroundMalignant pleural mesothelioma (MPM) often develops decades following exposure to asbestos. Current best therapy… Expand
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2012
2012
Biophysical characterization and stabilization of the recombinant albumin fusion protein sEphB4-HSA.
The use of albumin fusion proteins as therapeutic drug candidates is an attractive approach to design novel biopharmaceuticals… Expand
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Highly Cited
2009
Highly Cited
2009
The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade.
Kaposi sarcoma (KS) is associated with human herpesvirus (HHV)-8 and is dependent on the induction of vascular endothelial growth… Expand
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2009
2009
Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma.
Immunotherapy of cancer offers great promise, however translation into human studies has yielded relatively poor results to date… Expand
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