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Receptors, Prostaglandin E, EP3 Subtype

Known as: Receptor EP3, Prostanoid, Prostaglandin E2 Receptor, EP3 Subtype, Prostanoid Receptor EP3 
A subtype of prostaglandin E receptors that specifically couples to GTP-BINDING PROTEIN ALPHA SUBUNIT, GI and subsequently inhibits ADENYLYL CYCLASES… 
National Institutes of Health

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6 relations
In BloodPTGER3 geneagonistsantagonists & inhibitors

Papers overview

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Highly Cited
2010
Highly Cited
2010
PGE2 inhibits natural killer and gamma delta T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling.
2010
2010
Role of EP4 receptor and prostaglandin transporter in prostaglandin E2-induced alteration in colonic epithelial barrier integrity.
Prostaglandin E(2) (PGE(2)) is a proinflammatory lipid mediator produced in excess in inflammatory bowel disease (IBD). PGE(2… 
Highly Cited
2006
Highly Cited
2006
Critical Role of Prostaglandin E2 Overproduction in Impaired Pulmonary Host Response following Bone Marrow Transplantation1
The success of bone marrow transplantation (BMT) as a therapy for malignant and inherited disorders is limited by infectious… 
Highly Cited
2000
Highly Cited
2000
Expression and function of PPARgamma in rat and human vascular smooth muscle cells.
BACKGROUND Peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by fatty acids, eicosanoids, and insulin… 
Highly Cited
2000
Highly Cited
2000
Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo.
Expression of the inducible form of nitric oxide synthase (iNOS) in brain may contribute to neurotoxicity in Alzheimer's disease… 
Highly Cited
2000
Highly Cited
2000
Human Vascular Smooth Muscle Cells but Not Endothelial Cells Express Prostaglandin E Synthase
In a previous work, we postulated that endothelial cells possess only the following 2 enzymes involved in prostanoid synthesis… 
Highly Cited
1997
Highly Cited
1997
Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3).
Prostaglandin EP3 receptor subtype is a seven-membrane-spanning protein with multiple C-terminal tails generated by alternative… 
Review
1996
Review
1996
Functional and molecular aspects of renal prostaglandin receptors.
The diverse intrarenal effects of the prostaglandins (PG) are mediated by distinct guanine nucleotide regulatory protein (G… 
Highly Cited
1995
Highly Cited
1995
Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways.
The potent bronchoconstrictor and mitogenic actions of the peptide endothelin-1 (ET-1) on airway smooth muscle may contribute… 
Highly Cited
1993
Highly Cited
1993
Endothelin receptor subtypes in human and guinea‐pig pulmonary tissues
1 In this study the endothelin (ET) receptor subtypes mediating contractions produced by ET‐1 in human and guinea‐pig pulmonary… 
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