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A protective role for protease-activated receptors in the airways
The protection of cells in the upper intestine against digestion by pancreatic trypsin depends on the prostanoid prostaglandin E2 (PGE2) and is mediated by protease-activated receptors in theExpand
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In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline.
Responses of human bronchial strip preparations to contractile and relaxant agonists were measured in preparations from non-diseased and from asthmatic lung obtained 3-15 h post-mortem. The potenciesExpand
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Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways.
The potent bronchoconstrictor and mitogenic actions of the peptide endothelin-1 (ET-1) on airway smooth muscle may contribute significantly to the bronchial obstruction observed in asthma. However,Expand
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β1‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea
1 The relaxant effects to the β‐adrenoceptor agonists isoprenaline, adrenaline, noradrenaline, RO363, procaterol and fenoterol were investigated in carbachol‐contracted mouse isolated trachealExpand
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  • R. Goldie
  • Medicine
  • Clinical and experimental pharmacology…
  • 1 February 1999
1. There is an ever increasing volume of evidence implicating endothelin‐1 and its isoforms in a range of disease processes. These include asthma, pulmonary and essential systemic hypertension,Expand
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Altered expression and in vivo lung function of protease-activated receptors during influenza A virus infection in mice.
Protease-activated receptors (PARs) are widely distributed in human airways, and recent evidence indicates a role for PARs in the pathophysiology of inflammatory airway disease. To furtherExpand
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A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice.
Asthma is a complex inflammatory disorder involving obstruction, constriction, oedema, remodelling and hyperresponsiveness of the airways. These effects are induced by a raft of mediators, many ofExpand
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Co‐axial bioassay of a smooth muscle relaxant factor released from guinea‐pig tracheal epithelium
1 The ability of guinea‐pig trachea to release an epithelium‐derived relaxant factor (EpDRF) was assessed in a co‐axial bioassay system. 2 Histamine (100 μm) and methacholine (25 μm) causedExpand
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The endothelins in the pulmonary system.
Although initial research interest in the ETs was focused on their cardiovascular effects, it is now clearly established that these peptides have wide-ranging activities in the respiratory track.Expand
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Exogenously administered alpha-bungarotoxin binds to embryonic chick spinal cord: Implications for the toxin-induced arrest of naturally occurring motoneuron death
Administration of alpha-bungarotoxin and other curare-like drugs during embryogenesis arrests motoneuron death which normally occurs in the spinal cord from day 6 to day 10 of embryogenesis. TheExpand
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