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A protective role for protease-activated receptors in the airways
The protection of cells in the upper intestine against digestion by pancreatic trypsin depends on the prostanoid prostaglandin E2 (PGE2) and is mediated by protease-activated receptors in the… Expand
In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline.
- R. Goldie, D. Spina, P. Henry, K. Lulich, J. Paterson
- British journal of clinical pharmacology
- 1 December 1986
Responses of human bronchial strip preparations to contractile and relaxant agonists were measured in preparations from non-diseased and from asthmatic lung obtained 3-15 h post-mortem. The potencies… Expand
Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways.
- R. Goldie, P. Henry, P. G. Knott, G. Self, M. Luttmann, D. Hay
- American journal of respiratory and critical care…
- 1 November 1995
The potent bronchoconstrictor and mitogenic actions of the peptide endothelin-1 (ET-1) on airway smooth muscle may contribute significantly to the bronchial obstruction observed in asthma. However,… Expand
β1‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea
1 The relaxant effects to the β‐adrenoceptor agonists isoprenaline, adrenaline, noradrenaline, RO363, procaterol and fenoterol were investigated in carbachol‐contracted mouse isolated tracheal… Expand
ENDOTHELINS IN HEALTH AND DISEASE: AN OVERVIEW
- R. Goldie
- Clinical and experimental pharmacology…
- 1 February 1999
1. There is an ever increasing volume of evidence implicating endothelin‐1 and its isoforms in a range of disease processes. These include asthma, pulmonary and essential systemic hypertension,… Expand
Altered expression and in vivo lung function of protease-activated receptors during influenza A virus infection in mice.
- R. S. Lan, G. Stewart, R. Goldie, P. Henry
- Biology, Medicine
- American journal of physiology. Lung cellular and…
- 1 February 2004
Protease-activated receptors (PARs) are widely distributed in human airways, and recent evidence indicates a role for PARs in the pathophysiology of inflammatory airway disease. To further… Expand
A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice.
Asthma is a complex inflammatory disorder involving obstruction, constriction, oedema, remodelling and hyperresponsiveness of the airways. These effects are induced by a raft of mediators, many of… Expand
Co‐axial bioassay of a smooth muscle relaxant factor released from guinea‐pig tracheal epithelium
1 The ability of guinea‐pig trachea to release an epithelium‐derived relaxant factor (EpDRF) was assessed in a co‐axial bioassay system. 2 Histamine (100 μm) and methacholine (25 μm) caused… Expand
The endothelins in the pulmonary system.
Although initial research interest in the ETs was focused on their cardiovascular effects, it is now clearly established that these peptides have wide-ranging activities in the respiratory track.… Expand
Exogenously administered alpha-bungarotoxin binds to embryonic chick spinal cord: Implications for the toxin-induced arrest of naturally occurring motoneuron death
Administration of alpha-bungarotoxin and other curare-like drugs during embryogenesis arrests motoneuron death which normally occurs in the spinal cord from day 6 to day 10 of embryogenesis. The… Expand