Receptor, Melanocortin, Type 2

Known as: Receptor, MC2, Melanocortin 2 Receptor, Melanocortin Receptor 2 
A melanocortin receptor subtype found primarily in the ADRENAL CORTEX. It shows specificity for ADRENOCORTICOTROPIC HORMONE.
National Institutes of Health

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Papers overview

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Highly Cited
2013
Highly Cited
2013
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.
Melanocortin receptor accessory proteins (MRAPs) modulate signaling of melanocortin receptors in vitro. To investigate the… (More)
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2013
2013
Melanocortin 4 receptor becomes an ACTH receptor by coexpression of melanocortin receptor accessory protein 2.
Melanocortin 2 receptor (MC2R) is the only canonical ACTH receptor. Its functional expression requires the presence of an… (More)
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2009
2009
Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling.
MRAP, melanocortin 2 (MC2) receptor accessory protein, is required for trafficking by the MC2 (ACTH) receptor. MRAP is a single… (More)
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2009
2009
Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.
MC2 (ACTH) receptors require MC2 receptor accessory protein (MRAP) to reach the cell surface. In this study, we show that MRAP… (More)
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Highly Cited
2007
Highly Cited
2007
Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers.
The melanocortin-2 (MC2) receptor accessory protein (MRAP) is required for trafficking of the G protein-coupled MC2 receptor to… (More)
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Highly Cited
2007
Highly Cited
2007
Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis.
ACTH (i.e., corticotropin) is the principal regulator of the hypothalamus-pituitary-adrenal axis and stimulates steroidogenesis… (More)
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2007
2007
Differential regulation of the human adrenocorticotropin receptor [melanocortin-2 receptor (MC2R)] by human MC2R accessory protein isoforms alpha and beta in isogenic human embryonic kidney 293 cells…
The ACTH receptor [melanocortin-2 receptor (MC2R)] is the smallest known G protein-coupled receptor (GPCR). Herein, human MC2R… (More)
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Highly Cited
2005
Highly Cited
2005
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2
Familial glucocorticoid deficiency (FGD), or hereditary unresponsiveness to adrenocorticotropin (ACTH; OMIM 202200), is an… (More)
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Highly Cited
1996
Highly Cited
1996
Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line.
It has been known for many years that adipocytes express high affinity ACTH and alpha-melanocyte stimulating hormone (MSH… (More)
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Highly Cited
1993
Highly Cited
1993
Comparison of numerical models for computing underwater light fields.
Seven models for computing underwater radiances and irradiances by numerical solution of the radiative transfer equation are… (More)
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