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RXDX-101

 
National Institutes of Health

Papers overview

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2018
2018
10536Background: Entrectinib (RXDX-101) inhibits TRKA/B/C, ROS1, and ALK tyrosine kinases with IC50 < 2 nM. In vivo, entrectinib… Expand
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Review
2018
Review
2018
RTK plays important roles in many cellular signaling processes involved in cancer growth and development. ALK, TRKA, TRKB, TRKC… Expand
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Review
2016
Review
2016
Crizotinib is an oral inhibitor of anaplastic lymphoma kinase (ALK) with remarkable clinical activity in patients suffering from… Expand
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2016
2016
Neuroblastoma (NB) is one of the most common and deadly childhood solid tumors. These tumors are characterized by clinical… Expand
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2015
2015
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Purpose: Neuroblastoma (NB) is one of the most… Expand
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Highly Cited
2015
Highly Cited
2015
Introduction: Chromosomal rearrangements involving neurotrophic tyrosine kinase 1 (NTRK1) occur in a subset of non-small cell… Expand
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2014
2014
The Trk family of kinases, which include TrkA, TrkB and TrkC, are high affinity receptors for the neurotrophin family of nerve… Expand
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2014
2014
Methods: Karpas 299 lymphoma cells were mixed with plasma from patients treated with RXDX-101 and stimulated with human nerve… Expand
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