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10536Background: Entrectinib (RXDX-101) inhibits TRKA/B/C, ROS1, and ALK tyrosine kinases with IC50 < 2 nM. In vivo, entrectinib… Expand RTK plays important roles in many cellular signaling processes involved in cancer growth and development. ALK, TRKA, TRKB, TRKC… Expand Neuroblastoma (NB) is one of the most common and deadly childhood solid tumors. These tumors are characterized by clinical… Expand Crizotinib is an oral inhibitor of anaplastic lymphoma kinase (ALK) with remarkable clinical activity in patients suffering from… Expand Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA
Purpose: Neuroblastoma (NB) is one of the most… Expand Introduction: Chromosomal rearrangements involving neurotrophic tyrosine kinase 1 (NTRK1) occur in a subset of non-small cell… Expand The Trk family of kinases, which include TrkA, TrkB and TrkC, are high affinity receptors for the neurotrophin family of nerve… Expand Methods: Karpas 299 lymphoma cells were mixed with plasma from patients treated with RXDX-101 and stimulated with human nerve… Expand