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RWJ 58259

Known as: RWJ-58259 
National Institutes of Health

Papers overview

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2019
2019
A novel class of bivalent ligands targeting putative protease-activated receptor (PAR) heteromers has been prepared based upon… 
2016
2016
The discontinuation of PAR-1 antagonist RWJ-58259 beyond use as a biological probe is most likely due to it's short half-life in… 
2015
2015
Accumulated evidences indicate intestinal lesions play an important role in the pathogenesis of heatstroke. However, the… 
2009
2009
A significant improvement on the synthesis of the PAR-1 antagonist RWJ-58259 is described, which involves a base-related two-fold… 
Review
2003
Review
2003
It is well appreciated that thrombin as well as other proteases can act as signaling molecules that specifically regulate cells… 
Review
2003
Review
2003
Protease activated receptor-1 (PAR-1) is a key mediator of the cellular actions of alpha-thrombin. Thus, antagonism of this… 
Highly Cited
2003
Highly Cited
2003
Although it is well recognized that human platelet responses to α-thrombin are mediated by the protease-activated receptors PAR-1… 
Review
2003
Review
2003
Protease-activated receptors (PARs) represent a unique family of seven-transmembrane G-protein-coupled receptors, which are… 
Highly Cited
2001
Highly Cited
2001
Human platelets possess two distinct thrombin-activated receptors, PAR-1 (protease-activated receptor-1) and PAR-4, whereas human…