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RWJ 58259

Known as: RWJ-58259 
 
National Institutes of Health

Papers overview

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2018
2018
Several classes of ligands for Protease-Activated Receptors (PARs) have shown impressive anti-inflammatory and cytoprotective… Expand
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2016
2016
The discontinuation of PAR-1 antagonist RWJ-58259 beyond use as a biological probe is most likely due to it's short half-life in… Expand
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2015
2015
Accumulated evidences indicate intestinal lesions play an important role in the pathogenesis of heatstroke. However, the… Expand
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2015
2015
This thesis describes the investigation into the development of novel antagonists of the major thrombin receptor, protease… Expand
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2012
2012
By applying a diversity oriented synthesis strategy for the search of new antagonists of the thrombin receptor PAR1, a series of… Expand
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2009
2009
A significant improvement on the synthesis of the PAR-1 antagonist RWJ-58259 is described, which involves a base-related two-fold… Expand
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Review
2003
Review
2003
Protease activated receptor-1 (PAR-1) is a key mediator of the cellular actions of alpha-thrombin. Thus, antagonism of this… Expand
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Highly Cited
2003
Highly Cited
2003
Although it is well recognized that human platelet responses to alpha-thrombin are mediated by the protease-activated receptors… Expand
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Review
2003
Review
2003
Protease-activated receptors (PARs) represent a unique family of seven-transmembrane G-protein-coupled receptors, which are… Expand
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2001
2001
Human platelets possess two distinct thrombin-activated receptors, PAR-1 (protease-activated receptor-1) and PAR-4, whereas human… Expand
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