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RUNX1 gene

Known as: PEBP2A2, AMLCR1, RUNX1 
This gene plays a role in transcriptional regulation and cytogenetic aberrations are associated with several leukemias.
National Institutes of Health

Related topics

Related topics

10 relations
AML1-ETO Fusion Protein ExpressionEVI1-AML1 Fusion Protein ExpressionHomo sapiensREL gene

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RUNX1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Genetic Analysis of Gata3 and Runx1 in Mammary Tumor Formation
Genomic analysis of breast cancer (BC) has revealed the existence of recurrent copy number losses and mutations in GATA3 and… 
2014
2014
A Novel Xenograft Model of Cytogenetically Normal Acute Myeloid Leukemia Harboring RUNX1 and ASXL1 Mutations Demonstrates Residual Disease after Anthracycline/Cytarabine-Based Chemotherapy
Introduction: Cytogenetically normal acute myeloid leukemia (CN-AML) patients harboring RUNX1 mutations have a poor prognosis… 
2013
2013
NPM1 mutations occur rarely or not at all in chronic myeloid leukaemia patients in chronic phase or blast crisis
NPM1 mutations occur rarely or not at all in chronic myeloid leukaemia patients in chronic phase or blast crisis 
Review
2012
Review
2012
Transcription factor RUNX1
Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. RUNX1 controls hematopoiesis and angiogenesis… 
2008
2008
RUNX1 ABERRATIONS IN ETV6/RUNX1-POSITIVE AND ETV6/RUNX1-NEGATIVE PATIENTS: Its Hemato-Pathological and Prognostic Significance in a Large Cohort (619 Cases) of ALL
A large-cohort study (619) of acute lymphoblastic leukemia (ALL) revealed an ETV6/RUNX1 (previously known as TEL/AML1) incidence… 
2008
2008
RUNX1 Mutations in Normal Karyotype MDS Cooperate with Class I Mutations in the Progression to S-AML Following MDS.
The mechanism that may cause progression of myelodysplastic syndrom (MDS) to acute myeloid leukemia (AML) is genetically poorly… 
2007
2007
Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia.
2007
2007
High Frequency of AML1/RUNX1 Mutations in Specific Cytogenetic Subgroups in De Novo Acute Myeloid Leukemia.
Somatic mutations in the DNA-binding domain, the socalled Runt homology domain, of the AML1/RUNX1 gene have been identified to… 
2005
2005
AMLI a but not AMLI b Inhibits Erythroid Differentiation Induced by Sodium Butyrate and Enhances the Megakaryocytic Differentiation of K 562 Leukemia Cells 1
AMLI may play a role in growth and differentiation of cells along erythroid and/or megakaryocytic lineages, because a significant… 
Review
2001
Review
2001
[The role of TEL and AML1 genes in the pathogenesis of hematologic malignancies].
TEL and AML1 genes occur in a markedly high number of different aberrations in haematological malignancies. Besides the AML1, TEL… 
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