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RUNX1 gene

Known as: PEBP2A2, AMLCR1, RUNX1 
This gene plays a role in transcriptional regulation and cytogenetic aberrations are associated with several leukemias.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
In this review, we discuss disease-causing alterations of RUNT-related transcription factor 1 (RUNX1), a master regulator of… Expand
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Highly Cited
2015
Highly Cited
2015
To explore how RUNX1 mutations predispose to leukemia, we generated induced pluripotent stem cells (iPSCs) from 2 pedigrees with… Expand
Highly Cited
2013
Highly Cited
2013
The t(8;21) and inv(16) chromosomal aberrations generate the oncoproteins AML1-ETO (A-E) and CBFβ-SMMHC (C-S). The role of these… Expand
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Highly Cited
2013
Highly Cited
2013
To explore mechanisms contributing to the clinical heterogeneity of systemic mastocytosis (SM) and to suboptimal responses to… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy that is characterized by features of both a… Expand
Highly Cited
2009
Highly Cited
2009
Familial platelet disorder (FPD), a rare autosomal dominant disorder characterized by quantitative and qualitative platelet… Expand
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Highly Cited
2008
Highly Cited
2008
Familial platelet disorder with propensity to myeloid malignancy (FPD/AML) is an autosomal dominant syndrome characterized by… Expand
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Highly Cited
2007
Highly Cited
2007
The first haematopoietic stem cells (HSCs) appear in the aorta-gonad-mesonephros (AGM) region, major vitelline and umbilical… Expand
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Highly Cited
2007
Highly Cited
2007
Members of the Runx family of transcriptional regulators are required for the appropriate expression of CD4 and CD8 at discrete… Expand
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Highly Cited
1998
Highly Cited
1998
The polyomavirus enhancer binding protein 2alphaB (AML1/PEBP2alphaB/Cbfa2) plays a pivotal role in granulocyte colony-stimulating… Expand
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