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RPE65 gene

Known as: retinal pigment epithelium-specific protein 65kDa, retinol isomerase, BCO3 
National Institutes of Health

Related topics

Related topics

2 relations
LEBER CONGENITAL AMAUROSIS, TYPE II (disorder)retinoid isomerohydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Suppressed Crystallization of Rod-Disc Molecule by Surface Anchoring Confinement
Upon varying the thickness of liquid crystal (LC) cells and alternating their surface chemical and physical environments, phase… 
2012
2012
Design and Characterization of Heteroleptic Ruthenium Complexes Containing Benzimidazole Ligands for Dye-Sensitized Solar Cells: The Effect of Fluorine Substituents on Photovoltaic Performance.
We designed heteroleptic ruthenium complexes (RD12-RD15) containing fluoro-substituted benzimidazole ligands for dye-sensitized… 
2010
2010
Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease
Stargardt disease (STGD) is the major form of inherited juvenile macular degeneration. Pyridinium bis-retinoid A2E is a major… 
Review
2009
Review
2009
Focus on Molecules: RPE65, the visual cycle retinol isomerase.
2006
2006
Two Point Mutations of RPE65 from Patients with Retinal Dystrophies Decrease the Stability of RPE65 Protein and Abolish Its Isomerohydrolase Activity*
RPE65 is the isomerohydrolase in the retinoid visual cycle essential for recycling of 11-cis retinal, the chromophore for visual… 
2006
2006
Binding of RPE65 fragments to lipid monolayers and identification of its partners by glutathione S-transferase pull-down assays.
RPE65 is the major component of the retinal pigment epithelium (RPE) microsomal membrane, and it plays a critical role in the… 
2006
2006
Gene therapeutic prospects in early onset of severe retinal dystrophy: restoration of vision in RPE65 Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented…
Previous studies have tested gene replacement therapy in RPE65 deficient dogs using recombinant adeno-associated virus 2/2 (rAAV2… 
Highly Cited
2005
Highly Cited
2005
Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium
2005
2005
RPE65 surface epitopes, protein interactions, and expression in rod- and cone-dominant species.
PURPOSE RPE65 is an abundant protein necessary for the synthesis of the chromophore 11-cis retinal by the retinal pigment… 
2000
2000
A homozygous deletion in RPE65 in a small Sardinian family with autosomal recessive retinal dystrophy.
PURPOSE We have been engaged in an ongoing study to screen candidate genes for mutations in small families with various forms of… 
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