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retinoid isomerohydrolase

Known as: retinoid isomerase, retinol isomerase 
 
National Institutes of Health

Related topics

Related topics

2 relations
RPE65 gene

Broader (1)

cis-trans-Isomerases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Retinoids and Retinal Diseases.
Recent progress in molecular understanding of the retinoid cycle in mammalian retina stems from painstaking biochemical… Expand
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2012
2012
Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis.
PURPOSE Mutations in either retinoid isomerase (RPE65) or lecithin-retinol acyltransferase (LRAT) lead to Leber congenital… Expand
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Highly Cited
2009
Highly Cited
2009
Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate.
Inactivating mutations in the retinoid isomerase (RPE65) or lecithin:retinol acyltransferase (LRAT) genes cause Leber congenital… Expand
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2009
2009
In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death.
RPE65 is a retinoid isomerase required for the production of 11-cis-retinal, the chromophore of both cone and rod visual pigments… Expand
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2009
2009
NinaB Is Essential for Drosophila Vision but Induces Retinal Degeneration in Opsin-deficient Photoreceptors*
In animals, visual pigments are essential for photoreceptor function and survival. These G-protein-coupled receptors consist of a… Expand
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Highly Cited
2008
Highly Cited
2008
NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide
In animals, successful production of the visual chromophore (11-cis-retinal or derivatives thereof such as 11-cis-3-hydroxy… Expand
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2008
2008
Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments.
PURPOSE To define rod and cone function further in terms of visual cycle mechanism, the retinal phenotype resulting from Rpe65… Expand
Highly Cited
2005
Highly Cited
2005
Chicken retinas contain a retinoid isomerase activity that catalyzes the direct conversion of all-trans-retinol to 11-cis-retinol.
Vertebrate retinas contain two types of light-detecting cells. Rods subserve vision in dim light, while cones provide color… Expand
Highly Cited
1990
Highly Cited
1990
Uptake, processing and release of retinoids by cultured human retinal pigment epithelium.
Upon absorption of a photon, the 11-cis retinaldehyde chromophore of rhodopsin is isomerized and reduced to all-trans retinol… Expand
Highly Cited
1989
Highly Cited
1989
Solubilization and partial purification of retinyl ester synthetase and retinoid isomerase from bovine ocular pigment epithelium.
Studies reported previously from this laboratory have demonstrated that membranes from the pigment epithelium of the vertebrate… Expand
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