RMI1 gene

The Bloom's helicase ortholog, Sgs1, plays central roles to coordinate the formation and resolution of joint molecule… Expand

Repair of DNA double-strand breaks via homologous recombination can produce double Holliday junctions (dHJs) that require… Expand

Genetic evidence indicates that Saccharomyces cerevisiae Sgs1, Top3, and Rmi1 resolve topologically linked intermediates arising… Expand

A double Holliday junction (dHJ) is a central intermediate of homologous recombination that can be processed to yield crossover… Expand

Human topoisomerase IIIα is a type IA DNA topoisomerase that functions with BLM and RMI1 to resolve DNA replication and… Expand

RecQ helicases, together with topoisomerase III and Rmi1 family proteins, form an evolutionarily conserved complex that is… Expand

Bloom syndrome (BS), an autosomal recessive disorder, is marked by a high incidence of cancer early in life. Cells derived from… Expand

SGS1 encodes a DNA helicase whose homologues in human cells include the BLM, WRN, and RECQ4 genes, mutations in which lead to… Expand

Genome stability requires a set of RecQ-Top3 DNA helicase-topoisomerase complexes whose sole budding yeast homolog is encoded by… Expand

Bloom's syndrome (BS) is a rare human genetic disorder characterized by dwarfism, immunodeficiency, genomic instability and… Expand