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RHOB gene

Known as: APLYSIA RAS-RELATED HOMOLOG 6, RHOH6, RHOB 
This gene plays a role in signal transduction. It is involved in several cellular functions including cell adhesion, differentiation and motility.
National Institutes of Health

Related topics

Related topics

7 relations
Cytoskeletal ModelingHomo sapiensMorphogenesisSignal Transduction

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RHOB wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
RhoB regulates cell migration through altered focal adhesion dynamics
The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted… 
Highly Cited
2009
Highly Cited
2009
Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth.
Anaplastic thyroid carcinoma (ATC) is a highly aggressive form of the disease for which new therapeutic options are desperately… 
2008
2008
Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors.
Highly Cited
2007
Highly Cited
2007
RhoB Regulates PDGFR-&bgr; Trafficking and Signaling in Vascular Smooth Muscle Cells
Objective—RhoB is a small GTPase localized at the plasma membrane and endosomes that participates in the regulation of endocytic… 
Highly Cited
2006
Highly Cited
2006
TRIF–GEFH1–RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T‐cell activation
Dendritic cells (DC) play a central role in immune responses by presenting antigenic peptides to CD4+ T cells through MHCII… 
Highly Cited
2004
Highly Cited
2004
LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest
Members of the Sox family of transcription factors are involved in a number of crucial developmental processes, including sex… 
Highly Cited
2004
Highly Cited
2004
Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages.
Human alveolar macrophages (AMs) phagocytose Pneumocystis (Pc) organisms predominantly through mannose receptors, although the… 
Highly Cited
2004
Highly Cited
2004
Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression.
Highly Cited
1998
Highly Cited
1998
PRK1 Is Targeted to Endosomes by the Small GTPase, RhoB*
RhoB has been shown to be an endosomal GTPase both by immunocytochemistry and electron microscopy, however, its role in… 
Highly Cited
1991
Highly Cited
1991
Regulation of binding of rhoB p20 to membranes by its specific regulatory protein, GDP dissociation inhibitor.
We have previously purified from bovine brain cytosol a novel regulatory protein for the GTP-binding proteins of the rho gene… 
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