RFCNU

2-Chloroethyl nitrosocarbamoylcystamine or ICIG-1325 (CNCC) is a lipid-soluble isomeric mixture of nitrosoureas. Its dose-effect… (More)

Three new nitrosourea analogs (CNCC, RFCNU, and chlorozotocin) had comparable activities in vivo against L1210 leukemia cells. In… (More)

L1210 leukemia was used to compare the antitumor activities of three nitrosoureas (chlorozotocin, RFCNU and CNCC) encapsulated in… (More)

Three sugar derivatives of chloroethyl nitrosoureas: RPCNU, RFCNU and Chlorozotocin (CLZ) were examined for their effect on the… (More)

The results of three phase II clinical trials with three new analogues belonging to the family of nitrosoureas are reported. One… (More)

The disposition of 1-(2-chloroethyl)-3-[1'(5'-p-nitrobenzoyl-2',3'-isopropylidene)-alpha,beta-D-ribofuranosyl]-1-nitrosourea… (More)

We have compared the LD50 of three new nitrosourea derivatives, RFCNU, RPCNU, and chlorozotocin (CZT), in L1210 leukemia-bearing… (More)

Using high-performance liquid chromatography, the stability of RFCNU was monitored as a function of pH in aqueous buffers at 37… (More)

RFCNU or (chloro-2-ethyl)-l-(ribofuranosyl-isopropylidene-2', 3' paranitrobenzoate-5')-3 nitrosourea, a new synthetic nitrosourea… (More)

Four new nitrosourea derivatives represent an appreciable progress in the treatment and cure of L1210 leukemia. Their therapeutic… (More)