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RFCNU

Known as: N-(2-chloroethyl)-1-ribofuranosyl-2',3'-isopropylidene-5'-(p-nitrobenzoate)-3-nitrosourea 
National Institutes of Health

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Broader (1)

Nitrosourea Compounds

Papers overview

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1986
1986
Cytostatic action of two nitrosoureas derived from cysteamine
1 2‐Chloroethyl nitrosocarbamoylcystamine or ICIG‐1325 (CNCC) is a lipid‐soluble isomeric mixture of nitrosoureas. 2 Its dose… 
1985
1985
Comparison of the experimental antitumor activities of three nitrosourea derivatives chlorozotocin, RFCNU and CNCC encapsulated in liposomes with those in the free state.
L1210 leukemia was used to compare the antitumor activities of three nitrosoureas (chlorozotocin, RFCNU and CNCC) encapsulated in… 
1984
1984
In vivo acute hematotoxicity of N,N'-bis[N-(2-chloroethyl)-N-nitrosocarbamoyl]cystamine (CNCC), a new nitrosourea analog.
1983
1983
Comparative analysis of the immunopharmacological properties of three new nitrosourea analogues: RPCNU, RFCNU and Chlorozotocin.
1982
1982
Main metabolites of 1-(2-chloroethyl)-3-[1'-(5'-p-nitrobenzoyl-2',3'-isopropylidene)-alpha, beta-D-ribofuranosyl]-1-nitrosourea and 1-(2-chloroethyl)-3-(2',3', 4'-tri-O-acetyl-alpha, beta-D…
The metabolism of two glycosylnitrosoureas, 1-(2-chloroethyl)-3-[1'-(5'-p-nitrobenzoyl-2',3'-isopropylidene)-alpha, beta-D… 
1981
1981
Flow cytofluorometric analysis of the effects of new nitrosourea derivatives on proliferation of EMT 6 tumor cells "in vitro".
Examined by flow cytofluorometric analysis, the DNA distribution of EMT 6 tumor cells was highly perturbed after one hour of in… 
1980
1980
Disposition of the Carcinostatic Agent 1-(2-Chloroethyl)-3-[1′-(5′-p-nitrobenzoyl-2′,3′-isopropylidene)-α,β-d-ribofuranosyl]-1-nitrosourea in Animals
The disposition of 1-(2-Chloroethyl)-3-[1′-(5′- p -nitrobenzoyl-2′,3′-isopropylidene)-α,β-d-ribofuranosyl]-1-nitrosourea (RFCNU… 
1979
1979
Comparative pharmacology of three new nitrosourea analogues: RFCNU, RPCNU, and chlorozotocin
SummaryWe have compared the LD50 of three new nitrosourea derivatives, RFCNU, RPCNU, and chlorozotocin (CZT), in L1210 leukemia… 
1979
1979
Stability and preliminary pharmacokinetic studies of 1-(2-chloroethyl)-3-[1-(5'-paranitrobenzoyl-2',3'-isopropylidene)-alpha, beta-D-ribofuranosyl]-1-nitrosourea (RFCNU), a nonimmunosuppressive…
Using high-performance liquid chromatography, the stability of RFCNU was monitored as a function of pH in aqueous buffers at 37… 
1977
1977
Preliminary results of phase I and II clinical trials of RFCNU, a new nitrosourea sugar derivative, in digestive tract tumours.
RFCNU or (chloro-2-ethyl)-l-(ribofuranosyl-isopropylidene-2', 3' paranitrobenzoate-5')-3 nitrosourea, a new synthetic nitrosourea… 
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