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RFCNU

Known as: N-(2-chloroethyl)-1-ribofuranosyl-2',3'-isopropylidene-5'-(p-nitrobenzoate)-3-nitrosourea 
National Institutes of Health

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Nitrosourea Compounds

Papers overview

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1986
1986
Effects of three new nitrosourea analogs (CNCC, RFCNU and chlorozotocin) on in vivo destruction of L 1210 leukemia cells and on the immune response.
Three new nitrosourea analogs (CNCC, RFCNU, and chlorozotocin) had comparable activities in vivo against L1210 leukemia cells. In… 
1985
1985
Comparison of the experimental antitumor activities of three nitrosourea derivatives chlorozotocin, RFCNU and CNCC encapsulated in liposomes with those in the free state.
L1210 leukemia was used to compare the antitumor activities of three nitrosoureas (chlorozotocin, RFCNU and CNCC) encapsulated in… 
1982
1982
[Phase II study of 3 new nitrosoureas, 1 American (chlorozotocin) and 2 French (RFCNU and RPCNU)].
The results of three phase II clinical trials with three new analogues belonging to the family of nitrosoureas are reported. One… 
1981
1981
Flow cytofluorometric analysis of the effects of new nitrosourea derivatives on proliferation of EMT 6 tumor cells "in vitro".
Examined by flow cytofluorometric analysis, the DNA distribution of EMT 6 tumor cells was highly perturbed after one hour of in… 
1981
1981
In vivo enhancement of the experimental oncostatic effect of RFCNU by its encapsulation in liposomes.
1980
1980
Disposition of the Carcinostatic Agent 1-(2-Chloroethyl)-3-[1′-(5′-p-nitrobenzoyl-2′,3′-isopropylidene)-α,β-d-ribofuranosyl]-1-nitrosourea in Animals
The disposition of 1-(2-Chloroethyl)-3-[1′-(5′- p -nitrobenzoyl-2′,3′-isopropylidene)-α,β-d-ribofuranosyl]-1-nitrosourea (RFCNU… 
1980
1980
Disposition of the carcinostatic agent 1-(2-chloroethyl)-3-[1'-(5'-p-nitrobenzoyl-2',3'-isopropylidene)-alpha,beta-d-ribofuranosyl]-1-nitrosourea in animals.
The disposition of 1-(2-chloroethyl)-3-[1'(5'-p-nitrobenzoyl-2',3'-isopropylidene)-alpha,beta-D-ribofuranosyl]-1-nitrosourea… 
1979
1979
Stability and preliminary pharmacokinetic studies of 1-(2-chloroethyl)-3-[1-(5'-paranitrobenzoyl-2',3'-isopropylidene)-alpha, beta-D-ribofuranosyl]-1-nitrosourea (RFCNU), a nonimmunosuppressive…
Using high-performance liquid chromatography, the stability of RFCNU was monitored as a function of pH in aqueous buffers at 37… 
1979
1979
[Relationship of labeled molecules in the pharmacokinetic study of alkylating agents (chlorambucil, melphalan, mitoclomine) and glycosyl nitrosoureas (RFCNU and RPCNU)].
1975
1975
The oncostatic and immunosuppressive action of new nitrosourea derivatives containing sugar radicals.
Four new nitrosourea derivatives represent an appreciable progress in the treatment and cure of L1210 leukemia. Their therapeutic…