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The receptor tyrosine kinase ret protooncogene (RET) is implicated in the pathogenesis of several diseases and in several… Expand CONTEXT
RET is a tyrosine kinase transmembrane receptor expressed in two main alternative isoforms: RET9 and RET51. RET… Expand Molecular mechanisms that lead to congenital anomalies of kidneys and the lower urinary tract (CAKUT) are poorly understood. To… Expand ABSTRACT The receptor tyrosine kinase Ret plays a critical role in the development of the mammalian excretory and enteric nervous… Expand Alternative splicing of transcripts encoding the RET kinase receptor leads to isoforms differing in their cytoplasmic tail… Expand Ret, the receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family ligands (GFLs), is alternatively… Expand The RET receptor tyrosine kinase has a critical role in kidney organogenesis and the development of the enteric nervous system… Expand Gain-of-function mutations in the gene encoding the receptor tyrosine kinase RET have been identified as the aetiological factor… Expand Hirschsprung's disease (HSCR) is a common congenital malformation characterized by the absence of intramural ganglion cells of… Expand The mature mammalian kidney arises through a series of reciprocal inductive interactions between two different cell groups, the… Expand