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RAPGEF1 gene
Known as:
GRF2
, RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
, C3G
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This gene plays a role in signal transduction as well as protein binding and trafficking.
National Institutes of Health
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Related topics
Related topics
7 relations
RAPGEF1 protein, human
RAPGEF5 gene
RASGRF2 gene
RASGRF2 wt Allele
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RAPGEF1 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Nephrin Signaling Results in Integrin β1 Activation.
C. P. Dlugos
,
C. Picciotto
,
+13 authors
B. George
Journal of the American Society of Nephrology…
2019
Corpus ID: 157057796
BACKGROUND Patients with certain mutations in the gene encoding the slit diaphragm protein Nephrin fail to develop functional…
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2017
2017
C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis
Víctor Martín-Granado
,
Sara Ortiz-Rivero
,
+11 authors
C. Guerrero
Oncotarget
2017
Corpus ID: 19415605
Previous observations indicated that C3G (RAPGEF1) promotes α-granule release, evidenced by the increase in P-selectin exposure…
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2011
2011
TC-PTP Dephosphorylates the Guanine Nucleotide Exchange Factor C3G (RapGEF1) and Negatively Regulates Differentiation of Human Neuroblastoma Cells
A. Mitra
,
Srinivasan Kalayarasan
,
Vijay R. Gupta
,
V. Radha
PloS one
2011
Corpus ID: 3969019
The guanine nucleotide exchange factor, C3G (RapGEF1), functions in multiple signaling pathways involved in cell adhesion…
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2011
2011
Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population.
Li-li Qu
,
Bangshun He
,
+6 authors
Shukui Wang
Diabetes research and clinical practice
2011
Corpus ID: 22967522
2011
2011
Cytoskeletal remodeling by C3G to induce neurite-like extensions and inhibit motility in highly invasive breast carcinoma cells.
K. Dayma
,
V. Radha
Biochimica et biophysica acta
2011
Corpus ID: 205831423
2011
2011
Analysis of Potential Biomarkers and Modifier Genes Affecting the Clinical Course of CLN3 Disease
Anne-Hélène Lebrun
,
Parisa Moll-Khosrawi
,
+11 authors
A. Schulz
Molecular medicine
2011
Corpus ID: 4842894
Mutations in the CLN3 gene lead to juvenile neuronal ceroid lipofuscinosis, a pediatric neurodegenerative disorder characterized…
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2011
2011
Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans
K. Burgdorf
,
N. Grarup
,
+8 authors
O. Pedersen
PloS one
2011
Corpus ID: 5894165
Aims A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2…
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2011
2011
Frequent somatic demethylation of RAPGEF1/C3G intronic sequences in gastrointestinal and gynecological cancer.
J. Samuelsson
,
S. Alonso
,
T. Ruiz-Larroya
,
T. Cheung
,
Y. Wong
,
M. Perucho
International journal of oncology
2011
Corpus ID: 24577763
RAPGEF1 (also known as C3G and GRF2) is a guanine nucleotide exchange factor that releases GDP from the inactive Rap1 protein…
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Highly Cited
2008
Highly Cited
2008
Oncogenic mutations in GNAQ occur early in uveal melanoma.
M. Onken
,
L. Worley
,
+4 authors
J. Harbour
Investigative ophthalmology & visual science
2008
Corpus ID: 20924106
PURPOSE Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in…
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Highly Cited
2008
Highly Cited
2008
Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
Kyle J. Gaulton
,
C. Willer
,
+19 authors
K. Mohlke
Diabetes
2008
Corpus ID: 2849724
OBJECTIVE—Type 2 diabetes is a common complex disorder with environmental and genetic components. We used a candidate gene–based…
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