FAQ

RAPGEF1 gene

Known as: GRF2, C3G, GUANINE NUCLEOTIDE-RELEASING FACTOR 2 
This gene plays a role in signal transduction as well as protein binding and trafficking.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
010203019942018

Related topics

Related topics

5 relations

Narrower (1)

RAPGEF1 wt Allele
RAPGEF5 geneRASGRF2 geneRas Protein Specific Guanine Nucleotide Releasing Factor 2Signal Transduction

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
RAPGEF1 gene
Signal Transduction
RAPGEF1 wt Allele
Ras Protein Specific Guanine Nucleotide Releasing Factor 2
RASGRF2 gene
RAPGEF5 gene

Papers overview

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2014
2014
Complement factor H-related hybrid protein deregulates complement in dense deposit disease.
The renal disorder C3 glomerulopathy with dense deposit disease (C3G-DDD) pattern results from complement dysfunction and… (More)
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2008
2008
C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment.
Neuronal migration is integral to the development of the cerebral cortex and higher brain function. Cortical neuron migration… (More)
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2008
2008
Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
OBJECTIVE Type 2 diabetes is a common complex disorder with environmental and genetic components. We used a candidate gene-based… (More)
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2006
2006
Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels.
Anthocyanins are dietary flavonoids, which can prevent carcinogen-induced colorectal cancer in rats. Here, the hypotheses were… (More)
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2003
2003
Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b.
It was previously reported that Cbl-b associates with Crk-L in Jurkat T cells. However, the physiological significance of such… (More)
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Highly Cited
2001
Highly Cited
2001
Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis.
C3G is a guanine nucleotide exchange factor (GEF) for Rap1, and is activated via Crk adaptor protein. To understand the… (More)
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Highly Cited
1999
Highly Cited
1999
Absorption and metabolism of cyanidin 3-O-beta-D-glucoside in rats.
We have clarified for the first time how cyanidin 3-O-beta-D-glucoside (C3G), which is a potent antioxidant anthocyanin, is… (More)
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1997
1997
Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N)
A catalytically active fragment of the Rap-specific guanine-nucleotide exchange factor C3G was expressed in E coli. It was… (More)
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Highly Cited
1994
Highly Cited
1994
C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which… (More)
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1994
1994
Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk.
The widely expressed cellular Crk protein has the domain structure SH2-SH3-SH3. We have previously demonstrated that the more N… (More)
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