RAPGEF1 gene

Known as: GRF2, C3G, GUANINE NUCLEOTIDE-RELEASING FACTOR 2 
This gene plays a role in signal transduction as well as protein binding and trafficking.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
010203019942018

Papers overview

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2014
2014
The renal disorder C3 glomerulopathy with dense deposit disease (C3G-DDD) pattern results from complement dysfunction and… (More)
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2008
2008
Neuronal migration is integral to the development of the cerebral cortex and higher brain function. Cortical neuron migration… (More)
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2008
2008
OBJECTIVE Type 2 diabetes is a common complex disorder with environmental and genetic components. We used a candidate gene-based… (More)
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2006
2006
Anthocyanins are dietary flavonoids, which can prevent carcinogen-induced colorectal cancer in rats. Here, the hypotheses were… (More)
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2003
2003
It was previously reported that Cbl-b associates with Crk-L in Jurkat T cells. However, the physiological significance of such… (More)
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Highly Cited
2001
Highly Cited
2001
C3G is a guanine nucleotide exchange factor (GEF) for Rap1, and is activated via Crk adaptor protein. To understand the… (More)
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Highly Cited
1999
Highly Cited
1999
We have clarified for the first time how cyanidin 3-O-beta-D-glucoside (C3G), which is a potent antioxidant anthocyanin, is… (More)
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1997
1997
A catalytically active fragment of the Rap-specific guanine-nucleotide exchange factor C3G was expressed in E coli. It was… (More)
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Highly Cited
1994
Highly Cited
1994
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which… (More)
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1994
1994
The widely expressed cellular Crk protein has the domain structure SH2-SH3-SH3. We have previously demonstrated that the more N… (More)
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