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RAPGEF1 gene

Known as: GRF2, RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1, C3G 
This gene plays a role in signal transduction as well as protein binding and trafficking.
National Institutes of Health

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Related topics

7 relations
RAPGEF1 protein, humanRAPGEF5 geneRASGRF2 geneRASGRF2 wt Allele
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RAPGEF1 wt Allele

Papers overview

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2017
2017
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies
Background— Local ancestry may contribute to the disproportionate burden of subclinical and clinical cardiovascular disease among… Expand
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2011
2011
Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population.
Type 2 diabetes is a common complex disorder with environmental and genetic components. The aim of the present study was to… Expand
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2011
2011
TC-PTP Dephosphorylates the Guanine Nucleotide Exchange Factor C3G (RapGEF1) and Negatively Regulates Differentiation of Human Neuroblastoma Cells
The guanine nucleotide exchange factor, C3G (RapGEF1), functions in multiple signaling pathways involved in cell adhesion… Expand
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2011
2011
Frequent somatic demethylation of RAPGEF1/C3G intronic sequences in gastrointestinal and gynecological cancer.
RAPGEF1 (also known as C3G and GRF2) is a guanine nucleotide exchange factor that releases GDP from the inactive Rap1 protein… Expand
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2011
2011
Analysis of Potential Biomarkers and Modifier Genes Affecting the Clinical Course of CLN3 Disease
Mutations in the CLN3 gene lead to juvenile neuronal ceroid lipofuscinosis, a pediatric neurodegenerative disorder characterized… Expand
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2011
2011
Cytoskeletal remodeling by C3G to induce neurite-like extensions and inhibit motility in highly invasive breast carcinoma cells.
Cytoskeletal remodeling is responsible for cell plasticity and facilitates differentiation, motility and adherence related… Expand
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2011
2011
Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans
AIMS A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2… Expand
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2009
2009
RAPGEF1 gene variants associated with type 2 diabetes in the Korean population.
Under the activation of insulin receptors, glucose transporter 4 (Glut4) translocation is regulated by two signal transduction… Expand
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Highly Cited
2008
Highly Cited
2008
Oncogenic mutations in GNAQ occur early in uveal melanoma.
PURPOSE Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in… Expand
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Highly Cited
2008
Highly Cited
2008
Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
OBJECTIVE Type 2 diabetes is a common complex disorder with environmental and genetic components. We used a candidate gene-based… Expand
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