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RAPGEF1 gene

Known as: GRF2, RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1, C3G 
This gene plays a role in signal transduction as well as protein binding and trafficking.
National Institutes of Health

Papers overview

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2019
2019
BACKGROUND Patients with certain mutations in the gene encoding the slit diaphragm protein Nephrin fail to develop functional… 
2017
2017
Previous observations indicated that C3G (RAPGEF1) promotes α-granule release, evidenced by the increase in P-selectin exposure… 
2011
2011
The guanine nucleotide exchange factor, C3G (RapGEF1), functions in multiple signaling pathways involved in cell adhesion… 
2011
2011
Mutations in the CLN3 gene lead to juvenile neuronal ceroid lipofuscinosis, a pediatric neurodegenerative disorder characterized… 
2011
2011
Aims A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2… 
2011
2011
RAPGEF1 (also known as C3G and GRF2) is a guanine nucleotide exchange factor that releases GDP from the inactive Rap1 protein… 
Highly Cited
2008
Highly Cited
2008
PURPOSE Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in… 
Highly Cited
2008
Highly Cited
2008
OBJECTIVE—Type 2 diabetes is a common complex disorder with environmental and genetic components. We used a candidate gene–based…