FAQ

RAD51C gene

Known as: RAD51 Paralog C Gene, FANCO, RAD51, S. CEREVISIAE, HOMOLOG OF, C 
This gene plays a role in DNA repair and meiotic recombination.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
0102019982018

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Related topics

7 relations
DNA RepairFANCONI ANEMIA, COMPLEMENTATION GROUP OMeiotic RecombinationRAD51C protein, human
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RAD51C wt Allele

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
RAD51C gene
DNA Repair
Recombination, Genetic
Meiotic Recombination
recombinational repair
RAD51C protein, human

Papers overview

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2012
2012
Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families.
RAD51C was defined by Meindl et al. in 2010 as a high-risk gene involved in hereditary breast and ovarian cancers. Although this… (More)
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Highly Cited
2011
Highly Cited
2011
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor genes predispose to ovarian carcinomas, but… (More)
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Highly Cited
2011
Highly Cited
2011
RAD51C is a susceptibility gene for ovarian cancer.
A homozygous mutation in the RAD51C gene was recently found to cause Fanconi anemia-like disorder. Furthermore, six heterozygous… (More)
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Highly Cited
2010
Highly Cited
2010
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
Germline mutations in a number of genes involved in the recombinational repair of DNA double-strand breaks are associated with… (More)
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Highly Cited
2010
Highly Cited
2010
Mutation of the RAD51C gene in a Fanconi anemia–like disorder
Fanconi anemia (FA) is a rare chromosomal-instability disorder associated with a variety of developmental abnormalities, bone… (More)
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Highly Cited
2004
Highly Cited
2004
RAD51C is required for Holliday junction processing in mammalian cells.
During genetic recombination and the recombinational repair of chromosome breaks, DNA molecules become linked at points of strand… (More)
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2003
2003
The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis.
In Drosophila, mutations in double-strand DNA break (DSB) repair enzymes, such as spn-B, activate a meiotic checkpoint leading to… (More)
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Highly Cited
2001
Highly Cited
2001
Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Cells defective in any of the RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) are sensitive to DNA cross-linking agents… (More)
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Highly Cited
2001
Highly Cited
2001
Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.
Five Rad51-like proteins, referred to as Rad51 paralogs, have been described in vertebrates. We show that two of them, Rad51B and… (More)
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2000
2000
17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes.
Amplification of the 17q23 region occurs frequently in breast tumors. To characterize the structure of 17q23 amplicons and to… (More)
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