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R 1507

Known as: Anti-IGF-1R Monoclonal Antibody R1507, R-1507, R1507 
 
National Institutes of Health

Papers overview

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2015
2015
The insulin-like growth factor 1 receptor (IGF-1R) has surfaced as a significant target in multiple solid cancers due to its… Expand
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2013
2013
BACKGROUND Rhabdomyosarcoma (RMS) is an aggressive soft tissue tumour mainly affecting children and adolescents. Since survival… Expand
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Highly Cited
2012
Highly Cited
2012
AIMS A minority of patients with advanced sarcoma achieve prolonged progression free survival (PFS) with insulin growth factor… Expand
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Highly Cited
2011
Highly Cited
2011
PURPOSE R1507 is a selective, fully human, recombinant monoclonal antibody (immunoglobulin G1 subclass) against insulin-like… Expand
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2011
2011
PURPOSE To investigate whether indium-111-labeled R1507 ((111)In-R1507) immuno-SPECT (single-photon emission computed tomography… Expand
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Highly Cited
2011
Highly Cited
2011
PURPOSE The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma… Expand
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2011
2011
A subset of patients with Ewing's sarcoma responds to anti-insulin-like growth factor-1 receptor (IGF-1R) antibodies. Mechanisms… Expand
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2011
2011
The IGFs and the IGF type 1 receptor (IGF-1R) are essential mediators of normal mammary gland development in mice. IGF-I and the… Expand
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Highly Cited
2010
Highly Cited
2010
UNLABELLED The insulinlike growth factor 1 receptor (IGF-1R) is a new target for the treatment of breast cancer. Patients with… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE A phase I study was conducted to evaluate the pharmacokinetics, pharmacodynamics, safety, and tolerability of R1507-a… Expand
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