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R 1507

Known as: Anti-IGF-1R Monoclonal Antibody R1507, R-1507, R1507 
National Institutes of Health

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2 relations
RG 1507

Broader (1)

teprotumumab

Papers overview

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2014
2014
Abstract IA33: Combination targeted therapy in pediatric sarcomas
Our group, and many others have documented a crucial role for IGFIR signaling in several pediatric sarcomas. These studies, along… 
2014
2014
A NOVEL GLYCOENGINEERED BISPECIFIC ANTIBODY FORMAT FOR TARGETED INHIBITION OF EGFR AND IGF-1R DEMONSTRATING UNIQUE MOLECULAR PROPERTIES
Background : Bispecific antibodies are currently emerging as a promising new class of cancer therapeutics. Results : The novel… 
2013
2013
Large Molecule Therapeutics IGF-1 R Targeting Increases the Antitumor Effects of DNA-DamagingAgents in SCLCModel : AnOpportunity to Increase the Ef fi cacy of Standard Therapy
Insulin-like growth factor receptor-1 (IGF-1R) inhibition could be a relevant therapeutic approach in small cell lung cancer… 
2012
2012
Abstract 5578: IGF-1R nuclear staining in tumor cells identifies sarcoma patients with a prolonged progression free survival after IGF-1R monoclonal antibody therapy
Rationale A small proportion of patients with sarcoma achieves prolonged progression free survival (PFS) with insulin growth… 
Review
2012
Review
2012
Merck Serono spinouts
907 been carried out,” writes Renato Baserga, from the department of Cancer Biology, Thomas Jefferson University in Philadelphia… 
2011
2011
Imaging , Diagnosis , Prognosis Predicting IGF-1 R Therapy Response in Bone Sarcomas : Immuno-SPECT Imaging with Radiolabeled R 1507
Purpose: To investigate whether indium-111–labeled R1507 (In-R1507) immuno-SPECT (single— photon emission computed tomography), a… 
Highly Cited
2010
Highly Cited
2010
Fully Human Monoclonal Antibody Targeting IGF-1 R , Is Effective Alone and in Combination With Rapamycin in Inhibiting Growth of Osteosarcoma Xenografts
Osteosarcoma is the most common primary malignant bone tumor in children and young adults. The overall survival rate remains… 
2010
2010
ImmunoPET and immunoSPECT imaging of IGF-1R expression with radiolabeled R1507
2010
2010
Targeting Insulin-Like Growth Factor Signaling: Rational Combination Strategies
Activation of the insulin-like growth factor (IGF) pathway, by binding of the growth factors IGF-I and IGF-II to the receptors… 
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