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R-125224

National Institutes of Health

Papers overview

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2007
2007
In SCID Mice with Transplanted Joint Tissues from Rheumatism Patients, a Model Mice of Human Rheumatoid Arthritis, Anti-human Fas Antibody (R-125224) Distributes Specifically to Human Synovium
PurposeWe investigated the tissue distribution of a humanized anti-human Fas monoclonal antibody, R-125224, in SCID mice… 
2007
2007
Tissue distribution of humanized anti-human Fas monoclonal antibody (R-125224) based on fas antigen-antibody reaction in collagen-induced arthritis monkeys.
2006
2006
A humanized anti-human Fas antibody, R-125224, induces apoptosis in type I activated lymphocytes but not in type II cells.
Fas-mediated apoptosis plays an important role in the immune system, including the elimination of autoreactive lymphoid cells… 
2003
2003
Suppression of osteoclastogenesis in rheumatoid arthritis by induction of apoptosis in activated CD4+ T cells.
OBJECTIVE To examine the suppressive effect of anti-human Fas monoclonal antibody (mAb) on osteoclastogenesis in rheumatoid… 
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