In SCID Mice with Transplanted Joint Tissues from Rheumatism Patients, a Model Mice of Human Rheumatoid Arthritis, Anti-human Fas Antibody (R-125224) Distributes Specifically to Human Synovium

@article{Saito2006InSM,
  title={In SCID Mice with Transplanted Joint Tissues from Rheumatism Patients, a Model Mice of Human Rheumatoid Arthritis, Anti-human Fas Antibody (R-125224) Distributes Specifically to Human Synovium},
  author={Motoko Saito and Yasushi Yoshigae and Junichi Nakayama and Yukie Ogawa and Masahiko Ohtsuki and Atsushi Kurihara and Toshihiko Ikeda},
  journal={Pharmaceutical Research},
  year={2006},
  volume={24},
  pages={310-317}
}
We investigated the tissue distribution of a humanized anti-human Fas monoclonal antibody, R-125224, in SCID mice transplanted with synovial tissues from patients with rheumatoid arthritis (SCID-HuRAg mice). The binding kinetics of R-125224 was also determined, using isolated human synovial cells. Tissue distribution was assessed at 1, 24 and 168 h after intravenous administration of 125I-R-125224 to SCID-HuRAg mice (0.4 mg/kg). The in vitro binding of 125I-R-125224 to isolated human synovial… CONTINUE READING

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