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Quarfloxin

Known as: 3H-Benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide, 5-fluoro-N-(2-((2S)- 1-methyl-2-pyrrolidinyl)ethyl)-3-oxo-6-(3-pyrazinyl-1-pyrrolidinyl)-, 5-Fluoro-N-(2-((2S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-(3-(pyrazin-2- yl)pyrrolidin-1-yl)-3H-benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide, Quarfloxacin 
A fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA… 
National Institutes of Health

Related topics

Related topics

2 relations
CX 3543NCIt Antineoplastic Agent Terminology

Papers overview

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2008
2008
Quarfloxin (CX-3543) disrupts the Nucleolin/ rDNA quadruplex complexes, inhibits the elongation by RNA Polymerase I and exhibits potent antitumor activity in models of cancer
3301 RNA Polymerase I (Pol I) is a critical component of the Ribosome Biogenesis pathway and can be regulated with small… 
2008
2008
Submicromolar, Selective G‐Quadruplex Ligands from One Pot: Thermodynamic and Structural Studies of Human Telomeric DNA Binding by Azacyanines
The discovery of G-quadruplex structures in nucleic acid sequences associated with cancers has created intense interest in G… 
2007
2007
Pharmacokinetic findings from the phase I study of Quarfloxin (CX-3543): a protein-rDNA quadruplex inhibitor, in patients with advanced solid tumors.
B93 Background: Ribosomal RNA (rRNA) biosynthesis and subsequent ribosome assembly determine the proliferative state of cells… 
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