Pyrimidine-nucleoside phosphorylase

Known as: Nucleoside Phosphorylase, Pyrimidine, Pyrimidine Nucleoside Phosphorylase, Pyrimidine Phosphorylases 
Pentosyltransferases that catalyze the reaction between a pyrimidine nucleoside and orthophosphate to form a free pyrimidine and ribose-5-phosphate.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound, we sought to identify additional… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND AND PURPOSE Oxidative stress [i.e. increased levels of reactive oxygen species (ROS)] has been suggested as a… (More)
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Highly Cited
2007
Highly Cited
2007
Mutations in the nucleotide excision repair (NER) pathway can cause the xeroderma pigmentosum skin cancer predisposition syndrome… (More)
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Review
2004
Review
2004
  • Toxicology and applied pharmacology
  • 2004
Ultraviolet (UV) irradiation present in sunlight is an environmental human carcinogen. The toxic effects of UV from natural… (More)
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Review
2002
Review
2002
The reversible phosphorolysis of purine and pyrimidine nucleosides is an important biochemical reaction in the salvage pathway… (More)
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Highly Cited
2000
Highly Cited
2000
UV-damaged DNA-binding activity (UV-DDB) is deficient in some xeroderma pigmentosum group E individuals due to mutation of the… (More)
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Highly Cited
1999
Highly Cited
1999
Xeroderma pigmentosum variant (XP-V) represents one of the most common forms of this cancer-prone DNA repair syndrome. Unlike… (More)
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1998
1998
BACKGROUND Pyrimidine nucleoside phosphorylase (PYNP) catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide… (More)
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Highly Cited
1990
Highly Cited
1990
Cells from patients with Cockayne syndrome (CS) are hypersensitive to UV-irradiation but have an apparently normal ability to… (More)
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Highly Cited
1977
Highly Cited
1977
A guanine derivative with an acyclic side chain, 2-hydroxyethoxymethyl, at position 9 has potent antiviral activity [dose for 50… (More)
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