Pyrimidine-nucleoside phosphorylase

Known as: Nucleoside Phosphorylase, Pyrimidine, Pyrimidine Nucleoside Phosphorylase, Pyrimidine Phosphorylases 
Pentosyltransferases that catalyze the reaction between a pyrimidine nucleoside and orthophosphate to form a free pyrimidine and ribose-5-phosphate.
National Institutes of Health

Related topics

Related topics

9 relations
In BloodProcess of secretionThymidine PhosphorylaseUridine Phosphorylase
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor.
Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound, we sought to identify additional… (More)
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Comparative pharmacology of chemically distinct NADPH oxidase inhibitors
BACKGROUND AND PURPOSE Oxidative stress [i.e. increased levels of reactive oxygen species (ROS)] has been suggested as a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Recognition of DNA damage by the Rad4 nucleotide excision repair protein
Mutations in the nucleotide excision repair (NER) pathway can cause the xeroderma pigmentosum skin cancer predisposition syndrome… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Review
2004
Review
2004
Toxic effects of ultraviolet radiation on the skin.
  • Toxicology and applied pharmacology
  • 2004
Ultraviolet (UV) irradiation present in sunlight is an environmental human carcinogen. The toxic effects of UV from natural… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Review
2002
Review
2002
Structural analyses reveal two distinct families of nucleoside phosphorylases.
The reversible phosphorolysis of purine and pyrimidine nucleosides is an important biochemical reaction in the salvage pathway… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 4
  • table 2
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis.
UV-damaged DNA-binding activity (UV-DDB) is deficient in some xeroderma pigmentosum group E individuals due to mutation of the… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity.
Xeroderma pigmentosum variant (XP-V) represents one of the most common forms of this cancer-prone DNA repair syndrome. Unlike… (More)
Is this relevant?
1998
1998
The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation.
BACKGROUND Pyrimidine nucleoside phosphorylase (PYNP) catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide… (More)
Is this relevant?
Highly Cited
1990
Highly Cited
1990
The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA.
Cells from patients with Cockayne syndrome (CS) are hypersensitive to UV-irradiation but have an apparently normal ability to… (More)
Is this relevant?
Highly Cited
1977
Highly Cited
1977
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.
A guanine derivative with an acyclic side chain, 2-hydroxyethoxymethyl, at position 9 has potent antiviral activity [dose for 50… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?