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Proton-Coupled Folate Transporter

Known as: Solute Carrier Family 46, Member 1, Proton Coupled Folate Transporter, Folate Transporter, Proton-Coupled 
A symporter protein that couples the transport of FOLIC ACID with HYDROGEN IONS. The transporter functions most effectively under acidic conditions.
National Institutes of Health

Related topics

Related topics

12 relations
In BloodProcess of secretionSLC46A1 geneagonists

Narrower (3)

Proton-Coupled Folate Transporter, humanSlc46a1 protein, mouseSlc46a1 protein, rat

Papers overview

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2016
2016
Abstract 1362: Novel proton coupled folate transporter (PCFT) and reduced folate carrier (RFC) pharmacophore models for development of transporter-selective antifolates
RFC is a ubiquitously expressed folate transporter that is present in normal tissues and tumors. RFC is utilized by reduced… 
2014
2014
Abstract 782: Transmembrane 2-3 loop domain of the proton coupled folate transporter (PCFT) forms a novel “reentrant loop” structure and is functionally important
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA The proton coupled folate transporter (PCFT) is a proton… 
2012
2012
Adaptive transport of folic acid across renal epithelia in folate-deficient rats
Folate (vitamin B9) is an essential vitamin for a wide spectrum of biochemical reactions; however, unlike bacteria and plants… 
2012
2012
Neonatal and maternal iron status, but not serum folate, is related to placental expression of the proton coupled folate transporter (PCFT)
The proton coupled folate transporter (PCFT) has been identified as a major tissue folate transporter but this protein also… 
2011
2011
Fetal serum folate concentrations and placental folate transport in obese women.
2011
2011
O15. Non-invasive assessment of hemodynamics in early pregnancy.
2011
2011
Abstract 4121: Folate pathway in malignant pleural mesothelioma (MPM): Novel therapeutic opportunities due to folate receptor alpha overexpression
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background. The folate pathway is active in several… 
2011
2011
Knocking out the PCFT.
Although hereditary folate malabsorption was first described 50 years ago, only recently has the molecular basis of this disease… 
2011
2011
O16. Placental folate receptor alpha (FR-α) and proton coupled folate transporter (PCFT) mRNA and protein expression are decreased in pre-eclampsia.
2010
2010
The obligatory intestinal folate transporter PCFT ( SLC 46 A 1 ) is regulated by nuclear respiratory factor 1 ( NRF-1 )
Folates are essential vitamins that play a key role as one-carbon donors in a spectrum of biosynthetic pathways including RNA and… 
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