Proto-Oncogene Proteins c-bcr

Known as: c-bcr, Proto-Oncogene Protein, Proto-Oncogene Proteins, c-bcr, c-bcr Proteins 
A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1… (More)
National Institutes of Health

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BCR protein, human
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Highly Cited
2012
Highly Cited
2012
Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML)
In the face of competing first-line treatment options for CML, early prediction of prognosis on imatinib is desirable to assure… (More)
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Highly Cited
2012
Highly Cited
2012
A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation
The molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the B cell antigen receptor (pre-BCR) in… (More)
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Highly Cited
2007
Highly Cited
2007
Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.
Ikaros DNA-binding proteins are critical for the development of lymphocytes and other hematopoietic lineages, but it remains… (More)
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Review
2004
Review
2004
The biology of CML blast crisis.
Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the Philadelphia chromosome as the sole genetic… (More)
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Highly Cited
2002
Highly Cited
2002
Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene.
The developmental progression from pro-B to pre-B cells is controlled by pre-B cell receptor (pre-BCR) signaling which depends on… (More)
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Highly Cited
2002
Highly Cited
2002
Properties of a fetal multipotent neural stem cell (NEP cell).
Multipotent neural stem cells (NSCs) present in the developing neural tube (E10.5, neuroepithelial cells; NEP) were examined for… (More)
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Highly Cited
2000
Highly Cited
2000
Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.
Pre-B cell receptor (pre-BCR) expression is critical for B lineage development. The signaling events initiated by the pre-BCR… (More)
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Highly Cited
2000
Highly Cited
2000
Precursor B Cell Receptor–Dependent B Cell Proliferation and Differentiation Does Not Require the Bone Marrow or Fetal Liver Environment
The capacity of precursor B (pre-B) I cells from fetal liver and bone marrow to proliferate and differentiate into surface… (More)
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Highly Cited
1993
Highly Cited
1993
The ABL-BCR fusion gene is expressed in chronic myeloid leukemia.
Although the BCR-ABL hybrid gene on chromosome 22q-plays a pivotal role in the pathogenesis of chronic myeloid leukemia (CML… (More)
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Highly Cited
1991
Highly Cited
1991
The BCR gene encodes a novel serine/threonine kinase activity within a single exon.
Sequences encoded by the first exon of BCR that bind to the ABL SH2 domain are essential for the activation of the ABL tyrosine… (More)
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