Protein-arginine deiminase

Known as: peptidylarginine deiminase, protein-L-arginine iminohydrolase 
 
National Institutes of Health

Related topics

Related topics

3 relations
Arginine deiminasePADI4 gene

Broader (1)

Hydrolase

Papers overview

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Highly Cited
2013
Highly Cited
2013
Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.
Deep vein thrombosis and pulmonary embolism are major health problems associated with high mortality. Recently, DNA-based… (More)
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Highly Cited
2013
Highly Cited
2013
Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)
Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in humans and are associated with each… (More)
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Review
2010
Review
2010
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.
Rheumatoid arthritis (RA) is now clearly a true autoimmune disease with accumulating evidence of pathogenic disease-specific… (More)
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Highly Cited
2009
Highly Cited
2009
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
Peripheral blood neutrophils form highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs), that… (More)
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Highly Cited
2008
Highly Cited
2008
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells.
OBJECTIVES A gene-environment interaction between HLA-DR shared epitope genes and smoking in anti-cyclic citrullinated peptide… (More)
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Highly Cited
2008
Highly Cited
2008
Regulation of p53 target gene expression by peptidylarginine deiminase 4.
Histone Arg methylation has been correlated with transcriptional activation of p53 target genes. However, whether this… (More)
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Highly Cited
2004
Highly Cited
2004
Human PAD4 regulates histone arginine methylation levels via demethylimination.
Methylation of arginine (Arg) and lysine residues in histones has been correlated with epigenetic forms of gene regulation… (More)
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Highly Cited
2004
Highly Cited
2004
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages.
BACKGROUND Antibodies directed to proteins containing the non-standard amino acid citrulline, are extremely specific for… (More)
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Highly Cited
2003
Highly Cited
2003
ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets.
Selected for its high relative abundance, a protein spot of MW approximately 75 kDa, pI 5.5 was cored from a Coomassie-stained… (More)
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Highly Cited
2002
Highly Cited
2002
Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytes.
Peptidylarginine deiminase (PAD) deiminates arginine residues in proteins to citrulline residues Ca(2+) dependently. There are… (More)
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