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Protein-arginine deiminase
Known as:
peptidylarginine deiminase
, protein-L-arginine iminohydrolase
National Institutes of Health
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Related topics
Related topics
4 relations
Arginine deiminase
PADI4 gene
Broader (1)
Hydrolase
Narrower (1)
PADI2 protein, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice
K. Martinod
,
Mélanie Demers
,
+6 authors
D. Wagner
Proceedings of the National Academy of Sciences
2013
Corpus ID: 6819360
Deep vein thrombosis and pulmonary embolism are major health problems associated with high mortality. Recently, DNA-based…
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Highly Cited
2009
Highly Cited
2009
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
Y. Wang
,
Ming Li
,
+9 authors
S. Coonrod
The Journal of cell biology
2009
Corpus ID: 7452502
Peripheral blood neutrophils form highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs), that…
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Highly Cited
2008
Highly Cited
2008
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells
D. Makrygiannakis
,
M. Hermansson
,
+7 authors
A. Catrina
Annals of the rheumatic diseases
2008
Corpus ID: 25555746
Objectives: A gene–environment interaction between HLA-DR shared epitope genes and smoking in anti-cyclic citrullinated peptide…
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Highly Cited
2007
Highly Cited
2007
Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitro.
R. Raijmakers
,
A. J. W. Zendman
,
+7 authors
G. Pruijn
Journal of molecular biology
2007
Corpus ID: 19666113
Peptidylarginine deiminase (PAD) enzymes catalyze the conversion of arginine residues in proteins to citrulline residues…
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Highly Cited
2004
Highly Cited
2004
Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination
Y. Wang
,
J. Wysocka
,
+12 authors
S. Coonrod
Science
2004
Corpus ID: 1579362
Methylation of arginine (Arg) and lysine residues in histones has been correlated with epigenetic forms of gene regulation…
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Highly Cited
2004
Highly Cited
2004
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages.
E. Vossenaar
,
T. Radstake
,
+6 authors
W. V. van Venrooij
Annals of the rheumatic diseases
2004
Corpus ID: 25601397
BACKGROUND Antibodies directed to proteins containing the non-standard amino acid citrulline, are extremely specific for…
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Review
2004
Review
2004
Hypothesis: The Humoral Immune Response to Oral Bacteria Provides a Stimulus for the Development of Rheumatoid Arthritis
E. Rosenstein
,
R. Greenwald
,
L. J. Kushner
,
G. Weissmann
Inflammation
2004
Corpus ID: 39077759
Rheumatoid arthritis (RA) and adult periodontitis share common pathogenetic mechanisms and immunologic and pathological findings…
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Highly Cited
2002
Highly Cited
2002
Nuclear Localization of Peptidylarginine Deiminase V and Histone Deimination in Granulocytes*
K. Nakashima
,
T. Hagiwara
,
M. Yamada
The Journal of Biological Chemistry
2002
Corpus ID: 32082507
Peptidylarginine deiminase (PAD) deiminates arginine residues in proteins to citrulline residues Ca2+ dependently. There are four…
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Highly Cited
1999
Highly Cited
1999
Purification, Characterization, and Sequence Analysis of a Potential Virulence Factor from Porphyromonas gingivalis, Peptidylarginine Deiminase
W. McGraw
,
J. Potempa
,
D. Farley
,
J. Travis
Infection and Immunity
1999
Corpus ID: 24928817
ABSTRACT The initiation and progression of adult-onset periodontitis has been associated with infection of the gingival sulcus…
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Highly Cited
1996
Highly Cited
1996
Protein Unfolding by Peptidylarginine Deiminase
E. Tarcsa
,
L. Marekov
,
G. Mei
,
G. Melino
,
S. C. Lee
,
P. Steinert
The Journal of Biological Chemistry
1996
Corpus ID: 19466635
Peptidylarginine deiminases, which are commonly found in mammalian cells, catalyze the deimination of protein-bound arginine…
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