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Phagocytosis of apoptotic cells in homeostasis
This work focuses on the homeostatic removal of apoptotic cells in tissues and challenges the way dying cells themselves are viewed, as well as how healthy cells interact with and respond to dying cells.
Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
- Amelia E. Hochreiter-Hufford, Chang Sup Lee, +7 authors K. Ravichandran
- Biology, MedicineNature
- 24 April 2013
Data are identified to identify apoptotic cells as a new type of cue that induces signalling via the phosphatidylserine receptor BAI1 to promote fusion of healthy myoblasts, with important implications for muscle development and repair.
PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection
It is concluded that PAD4-mediated NET formation is dispensable in a mouse model of influenza A infection.
A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents.
- A. Gaultier, S. Arandjelovic, +7 authors W. Campana
- Biology, MedicineThe Journal of clinical investigation
- 2 January 2008
The results show that sLRP-alpha is biologically active and may attenuate neuropathic pain in the PNS, and the function of LRP1 may reflect the integrated activities of the membrane-anchored and shed forms of L RP1.
Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.
It is proposed that LRP-1 suppresses expression of inflammatory mediators indirectly, by regulating TNFR1-dependent cell signaling through the I kappaB kinase-NF-kappaB pathway.
ATP Induces Protein Arginine Deiminase 2-Dependent Citrullination in Mast Cells through the P2X7 Purinergic Receptor
- S. Arandjelovic, Katherine McKenney, Sunamita S Leming, K. Mowen
- Biology, MedicineThe Journal of Immunology
- 15 October 2012
The results suggest that P2X7 activation of mast cells may play a role in inflammation by providing P AD2 and PAD2 substrates access to the extracellular space.
Hematopoietic pannexin 1 function is critical for neuropathic pain
- Janelle L Weaver, S. Arandjelovic, +12 authors D. Bayliss
- MedicineScientific reports
- 14 February 2017
It is shown that Pannexin 1 in hematopoietic cells is required for pain-like responses following nerve injury in mice, and inhibition of Panx1 may be useful in treating neuropathic pain, and a potential therapeutic target is suggested.
PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis
- Amanda S. Rohrbach, S. Hemmers, S. Arandjelovic, M. Corr, K. Mowen
- MedicineArthritis Research & Therapy
- 2 May 2012
PAD4 WT and KO mice develop disease in the K/BxN serum transfer model of arthritis with similar severity and kinetics, indicating that PAD4 is dispensable in this effector phase model of disease.
Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta.
It is demonstrated that peptides, derived from the structure of human alpha(2)M (amino acids 714-729), bind directly to T GF-beta1 and block the binding of TGF- beta1 to the type I and II TGF -beta receptors.
Identification of the Low Density Lipoprotein (LDL) Receptor-related Protein-1 Interactome in Central Nervous System Myelin Suggests a Role in the Clearance of Necrotic Cell Debris*
- Anthony Fernández-Castañeda, S. Arandjelovic, +4 authors A. Gaultier
- Biology, MedicineThe Journal of Biological Chemistry
- 21 December 2012
It is proposed that LRP1 functions as a receptor for endocytosis of intracellular components released during cellular damage and necrosis, which could maintain homeostasis in the central nervous system.