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Protein Tob2

Known as: Protein Tob4, TOB2, Transducer of ErbB-2 2 
Protein Tob2 (344 aa, ~37 kDa) is encoded by the human TOB2 gene. This protein plays a role in cell cycle arrest.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Cycle ControlGenes, RegulatorGenes, cdcInhibition of Cell Proliferation
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Papers overview

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Highly Cited
2014
Highly Cited
2014
MiR-422a as a Potential Cellular MicroRNA Biomarker for Postmenopausal Osteoporosis
Background MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that regulate gene expression by targeting mRNAs… Expand
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2014
2014
MicroRNA-378 functions as an onco-miR in nasopharyngeal carcinoma by repressing TOB2 expression.
Increasing evidence indicates that microRNAs (miRNAs) has been implicated in the progression and metastasis of numerous cancers… Expand
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Highly Cited
2013
Highly Cited
2013
MicroRNA-322 (miR-322) and Its Target Protein Tob2 Modulate Osterix (Osx) mRNA Stability*
Background: miRNAs exert important roles during osteoblast proliferation and differentiation. Results: miR-322 induces expression… Expand
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Highly Cited
2012
Highly Cited
2012
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We… Expand
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Highly Cited
2011
Highly Cited
2011
Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation
The c-Myc transcription factor activates a cascade of downstream targets to form a complex transcriptional program that… Expand
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Highly Cited
2011
Highly Cited
2011
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated… Expand
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2008
2008
Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation
Mice lacking tob2, a member of the antiproliferative family genes, had decreased bone mass, and the number of osteoclasts… Expand
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2002
2002
PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis
PC3TIS21/BTG2 is member of a novel family of antiproliferative genes (BTG1, ANA/BTG3, PC3B, TOB, and TOB2) that play a role in… Expand
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Review
2001
Review
2001
The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?
  • F. Tirone
  • Journal of cellular physiology
  • 2001
    • Corpus ID: 10117199
PC3(TIS21/BTG2) is the founding member of a family of genes endowed with antiproliferative properties, namely BTG1, ANA/BTG3… Expand
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Highly Cited
1999
Highly Cited
1999
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases
Human cDNAs encoding a novel member of Tob/BTG1 anti-proliferative family proteins were cloned. The putative protein product… Expand
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