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Protein Tob2

Known as: Protein Tob4, TOB2, Transducer of ErbB-2 2 
Protein Tob2 (344 aa, ~37 kDa) is encoded by the human TOB2 gene. This protein plays a role in cell cycle arrest.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Cycle ControlGenes, RegulatorGenes, cdcInhibition of Cell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Three TOB1-related YABBY genes are required to maintain proper function of the spikelet and branch meristems in rice.
YABBY genes play important roles in the development of lateral organs such as leaves and floral organs in Angiosperms. However… 
Highly Cited
2014
Highly Cited
2014
MiR-422a as a Potential Cellular MicroRNA Biomarker for Postmenopausal Osteoporosis
Background MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that regulate gene expression by targeting mRNAs… 
2014
2014
MicroRNA-378 functions as an onco-miR in nasopharyngeal carcinoma by repressing TOB2 expression.
Increasing evidence indicates that microRNAs (miRNAs) has been implicated in the progression and metastasis of numerous cancers… 
Highly Cited
2013
Highly Cited
2013
MicroRNA-322 (miR-322) and Its Target Protein Tob2 Modulate Osterix (Osx) mRNA Stability*
Background: miRNAs exert important roles during osteoblast proliferation and differentiation. Results: miR-322 induces expression… 
Highly Cited
2012
Highly Cited
2012
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We… 
Highly Cited
2011
Highly Cited
2011
Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation
The c-Myc transcription factor activates a cascade of downstream targets to form a complex transcriptional program that… 
Highly Cited
2011
Highly Cited
2011
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated… 
Highly Cited
2003
Highly Cited
2003
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling
Review
2001
Review
2001
The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?
  • F. Tirone
  • Journal of Cellular Physiology
  • 2001
  • Corpus ID: 10117199
PC3(TIS21/BTG2) is the founding member of a family of genes endowed with antiproliferative properties, namely BTG1, ANA/BTG3… 
Highly Cited
1999
Highly Cited
1999
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases
Human cDNAs encoding a novel member of Tob/BTG1 anti-proliferative family proteins were cloned. The putative protein product… 
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