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Protein Tob2
Known as:
Protein Tob4
, TOB2
, Transducer of ErbB-2 2
Protein Tob2 (344 aa, ~37 kDa) is encoded by the human TOB2 gene. This protein plays a role in cell cycle arrest.
National Institutes of Health
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Related topics
Related topics
7 relations
Cell Cycle Control
Genes, Regulator
Genes, cdc
Inhibition of Cell Proliferation
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Three TOB1-related YABBY genes are required to maintain proper function of the spikelet and branch meristems in rice.
Wakana Tanaka
,
T. Toriba
,
H. Hirano
New Phytologist
2017
Corpus ID: 4799782
YABBY genes play important roles in the development of lateral organs such as leaves and floral organs in Angiosperms. However…
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2017
2017
MiR-5100 promotes osteogenic differentiation by targeting Tob2
Huaxin Wang
,
Yazhou Cui
,
+5 authors
Jinxiang Han
Journal of Bone and Mineral Metabolism
2017
Corpus ID: 21897201
MicroRNAs have emerged as pivotal regulators in various physiological and pathological processes, including osteogenesis. Here we…
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2015
2015
Upregulation of miR‐362‐3p Modulates Proliferation and Anchorage‐Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma
Hongxing Shen
,
Wenjuan Li
,
+4 authors
Youjun Li
Journal of Cellular Biochemistry
2015
Corpus ID: 37699488
The dysregulation of microRNAs (miRNAs) contributes to the pathogenesis of human malignancies, and miRNA expression can be…
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Highly Cited
2014
Highly Cited
2014
MiR-422a as a Potential Cellular MicroRNA Biomarker for Postmenopausal Osteoporosis
Z. Cao
,
B. Moore
,
+4 authors
P. Xiao
PLoS ONE
2014
Corpus ID: 16695403
Background MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that regulate gene expression by targeting mRNAs…
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Highly Cited
2013
Highly Cited
2013
MicroRNA-322 (miR-322) and Its Target Protein Tob2 Modulate Osterix (Osx) mRNA Stability*
Beatriz Gámez
,
Edgardo Rodríguez-Carballo
,
R. Bartrons
,
J. L. Rosa
,
F. Ventura
Journal of Biological Chemistry
2013
Corpus ID: 26779276
Background: miRNAs exert important roles during osteoblast proliferation and differentiation. Results: miR-322 induces expression…
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2012
2012
Tob2 Inhibits Peroxisome Proliferator-Activated Receptor γ2 Expression by Sequestering Smads and C/EBPα during Adipocyte Differentiation
A. Takahashi
,
M. Morita
,
Kazumasa Yokoyama
,
Toru Suzuki
,
Tadashi Yamamoto
Molecular and Cellular Biology
2012
Corpus ID: 206824659
ABSTRACT Adipogenesis is an important component of adipose tissue development and is critically related to obesity. A cascade of…
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Highly Cited
2011
Highly Cited
2011
Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation
Mengling Feng
,
Zhimei Li
,
+4 authors
Qiang Yu
Oncogene
2011
Corpus ID: 6089502
The c-Myc transcription factor activates a cascade of downstream targets to form a complex transcriptional program that…
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Highly Cited
2003
Highly Cited
2003
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling
Y. Yoshida
,
A. V. Bubnoff
,
+7 authors
Ken W. Y. Cho
Mechanisms of Development
2003
Corpus ID: 728736
2002
2002
PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis
G. Corrente
,
D. Guardavaccaro
,
F. Tirone
NeuroReport
2002
Corpus ID: 4996878
PC3TIS21/BTG2 is member of a novel family of antiproliferative genes (BTG1, ANA/BTG3, PC3B, TOB, and TOB2) that play a role in…
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Review
2001
Review
2001
The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?
F. Tirone
Journal of Cellular Physiology
2001
Corpus ID: 10117199
PC3(TIS21/BTG2) is the founding member of a family of genes endowed with antiproliferative properties, namely BTG1, ANA/BTG3…
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