Protein Tob2

Known as: Protein Tob4, TOB2, Transducer of ErbB-2 2 
Protein Tob2 (344 aa, ~37 kDa) is encoded by the human TOB2 gene. This protein plays a role in cell cycle arrest.
National Institutes of Health

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Cell Cycle ControlGenes, RegulatorGenes, cdcInhibition of Cell Proliferation
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Papers overview

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2014
2014
MicroRNA-378 functions as an onco-miR in nasopharyngeal carcinoma by repressing TOB2 expression.
Increasing evidence indicates that microRNAs (miRNAs) has been implicated in the progression and metastasis of numerous cancers… (More)
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2013
2013
MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability.
Osteogenesis depends on a coordinated network of signals and transcription factors such as Runx2 and Osterix. Recent evidence… (More)
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Highly Cited
2012
Highly Cited
2012
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We… (More)
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2011
2011
Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation
The c-Myc transcription factor activates a cascade of downstream targets to form a complex transcriptional program that… (More)
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Highly Cited
2011
Highly Cited
2011
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated… (More)
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2008
2008
Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation.
Mice lacking tob2, a member of the antiproliferative family genes, had decreased bone mass, and the number of osteoclasts… (More)
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2003
2003
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling
Tob inhibits bone morphogenetic protein (BMP) signaling by interacting with receptor-regulated Smads in osteoblasts. Here we… (More)
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Review
2001
Review
2001
The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?
PC3(TIS21/BTG2) is the founding member of a family of genes endowed with antiproliferative properties, namely BTG1, ANA/BTG3… (More)
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2000
2000
Cloning and characterization of the mouse tob2 gene.
Human Tob2 is a member of the Tob/BTG1 anti-proliferative family of proteins. Here, we report the molecular cloning and… (More)
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1999
1999
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases
Human cDNAs encoding a novel member of Tob/BTG1 anti-proliferative family proteins were cloned. The putative protein product… (More)
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