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Protein Tob2

Known as: Protein Tob4, TOB2, Transducer of ErbB-2 2 
Protein Tob2 (344 aa, ~37 kDa) is encoded by the human TOB2 gene. This protein plays a role in cell cycle arrest.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Cycle ControlGenes, RegulatorGenes, cdcInhibition of Cell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Three TOB1-related YABBY genes are required to maintain proper function of the spikelet and branch meristems in rice.
YABBY genes play important roles in the development of lateral organs such as leaves and floral organs in Angiosperms. However… 
2017
2017
MiR-5100 promotes osteogenic differentiation by targeting Tob2
MicroRNAs have emerged as pivotal regulators in various physiological and pathological processes, including osteogenesis. Here we… 
2015
2015
Upregulation of miR‐362‐3p Modulates Proliferation and Anchorage‐Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma
The dysregulation of microRNAs (miRNAs) contributes to the pathogenesis of human malignancies, and miRNA expression can be… 
Highly Cited
2014
Highly Cited
2014
MiR-422a as a Potential Cellular MicroRNA Biomarker for Postmenopausal Osteoporosis
Background MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that regulate gene expression by targeting mRNAs… 
Highly Cited
2013
Highly Cited
2013
MicroRNA-322 (miR-322) and Its Target Protein Tob2 Modulate Osterix (Osx) mRNA Stability*
Background: miRNAs exert important roles during osteoblast proliferation and differentiation. Results: miR-322 induces expression… 
2012
2012
Tob2 Inhibits Peroxisome Proliferator-Activated Receptor γ2 Expression by Sequestering Smads and C/EBPα during Adipocyte Differentiation
ABSTRACT Adipogenesis is an important component of adipose tissue development and is critically related to obesity. A cascade of… 
Highly Cited
2011
Highly Cited
2011
Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation
The c-Myc transcription factor activates a cascade of downstream targets to form a complex transcriptional program that… 
Highly Cited
2003
Highly Cited
2003
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling
2002
2002
PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis
PC3TIS21/BTG2 is member of a novel family of antiproliferative genes (BTG1, ANA/BTG3, PC3B, TOB, and TOB2) that play a role in… 
Review
2001
Review
2001
The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?
PC3(TIS21/BTG2) is the founding member of a family of genes endowed with antiproliferative properties, namely BTG1, ANA/BTG3… 
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