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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
TLDR
Genetic deletion of Lgr4/5 in mouse intestinal crypt cultures phenocopies withdrawal of Rspo1 and can be rescued by Wnt pathway activation, which will guide future studies towards the application of R-spondins for regenerative purposes of tissues expressing Lgr5 homologues.
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.
TLDR
The induction of Skp2 and Cks1 degradation in G1 represents a principal mechanism by which APC/C(Cdh1) prevents the unscheduled degradation of SCF(Skp2-Cks1) substrates and maintains the G1 state.
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
TLDR
It is shown that repression of ribosomal RNA genes by JHDM1B is dependent on its JmjC domain, which is necessary for the specific demethylation of trimethylated lysine 4 on histone H3 in the nucleolus, and a JmJC-domain-dependent negative effect of JHDm1B on cell size and cell proliferation is shown.
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.
TLDR
The results show that beta-TrCP has a crucial role in mediating the response to DNA damage through Cdc25A degradation through the Skp1/Cul1/F-box protein complex, and that it may function in the intra-S-phase checkpoint.
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
TLDR
expression in cultured cells of a stable PDCD4 mutant that is unable to bind betaTRCP inhibited translation of an mRNA with a structured 5'UTR, resulted in smaller cell size, and slowed down cell cycle progression.
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
TLDR
It is shown that Id2 interacts with the core subunits of APC/C and Cdh1 in primary neurons, indicating that deregulated Id activity might be useful to reprogramme quiescent neurons into the axonal growth mode.
The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
TLDR
It is reported that the HECT-domain ubiquitin ligase Huwe1 ubiquitinates the N-Myc oncoprotein through Lys 48-mediated linkages and targets it for destruction by the proteasome, indicating that Huwe 1 links destruction of N- myc to the quiescent state that complements differentiation in the neural tissue.
Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.
TLDR
Beta-Trcp1 regulates the timely order of meiotic and mitotic events and it is demonstrated that Emi1 is a bona fide substrate of beta-TrCP1.
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