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Protein Sprouty Homolog 2

Known as: SPRY2, Sprouty 2, Spry-2 
Protein sprouty homolog 2 (315 aa, ~35 kDa) is encoded by the human SPRY2 gene. This protein is involved in antagonism of growth factor signaling… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
MicroRNAs are short regulatory RNAs. A growing body of data implicates altered miRNA participate in the development of cancers… Expand
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Highly Cited
2008
Highly Cited
2008
The posttranscriptional regulator, microRNA-21 (miR-21), is up-regulated in many forms of cancer, as well as during cardiac… Expand
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Highly Cited
2006
Highly Cited
2006
The Sprouty proteins are increasingly being recognized to be deregulated in various types of cancers. This deregulation is often… Expand
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Review
2004
Review
2004
Sprouty proteins are evolutionarily conserved inducible inhibitors of signalling by receptor tyrosine kinases. They have been… Expand
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Highly Cited
2004
Highly Cited
2004
Sprouty (Spry) proteins were found to be endogenous inhibitors of the Ras/mitogen-activated protein kinase pathway that play an… Expand
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Highly Cited
2004
Highly Cited
2004
The kidney is a classic model for studying mechanisms of inductive tissue interactions associated with the epithelial branching… Expand
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Highly Cited
2004
Highly Cited
2004
A strict regulation of hepatocyte growth factor/scatter factor (HGF/SF)-Met signaling is essential for its appropriate function… Expand
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Highly Cited
2004
Highly Cited
2004
BRAF mutations result in constitutively active BRAF kinase activity and increased extracellular signal-regulated kinase (ERK… Expand
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Highly Cited
2002
Highly Cited
2002
Sprouty (Spry) inhibits signalling by receptor tyrosine kinases; however, the molecular mechanism underlying this function has… Expand
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Highly Cited
2001
Highly Cited
2001
Sprouty (SPRY) was first identified in a genetic screen in Drosophila as an antagonist of fibroblast and epidermal growth factor… Expand
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