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Protein Sprouty Homolog 2

Known as: SPRY2, Sprouty 2, Spry-2 
Protein sprouty homolog 2 (315 aa, ~35 kDa) is encoded by the human SPRY2 gene. This protein is involved in antagonism of growth factor signaling… Expand
National Institutes of Health

Related topics

Related topics

5 relations
Cytoplasmic matrixSPRY2 geneSignal TransductionSignal Transduction Inhibition
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Papers overview

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Highly Cited
2010
Highly Cited
2010
miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2.
MicroRNAs are short regulatory RNAs. A growing body of data implicates altered miRNA participate in the development of cancers… Expand
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Highly Cited
2008
Highly Cited
2008
MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths.
The posttranscriptional regulator, microRNA-21 (miR-21), is up-regulated in many forms of cancer, as well as during cardiac… Expand
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Highly Cited
2006
Highly Cited
2006
Sprouty 2, an inhibitor of mitogen-activated protein kinase signaling, is down-regulated in hepatocellular carcinoma.
The Sprouty proteins are increasingly being recognized to be deregulated in various types of cancers. This deregulation is often… Expand
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Review
2004
Review
2004
Modulation of signalling by Sprouty: a developing story
Sprouty proteins are evolutionarily conserved inducible inhibitors of signalling by receptor tyrosine kinases. They have been… Expand
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Highly Cited
2004
Highly Cited
2004
The Ras/Mitogen-Activated Protein Kinase Pathway Inhibitor and Likely Tumor Suppressor Proteins, Sprouty 1 and Sprouty 2 Are Deregulated in Breast Cancer
Sprouty (Spry) proteins were found to be endogenous inhibitors of the Ras/mitogen-activated protein kinase pathway that play an… Expand
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Highly Cited
2004
Highly Cited
2004
Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
The kidney is a classic model for studying mechanisms of inductive tissue interactions associated with the epithelial branching… Expand
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Highly Cited
2004
Highly Cited
2004
Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis
A strict regulation of hepatocyte growth factor/scatter factor (HGF/SF)-Met signaling is essential for its appropriate function… Expand
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Highly Cited
2004
Highly Cited
2004
SPRY2 Is an Inhibitor of the Ras/Extracellular Signal-Regulated Kinase Pathway in Melanocytes and Melanoma Cells with Wild-Type BRAF but Not with the V599E Mutant
BRAF mutations result in constitutively active BRAF kinase activity and increased extracellular signal-regulated kinase (ERK… Expand
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Highly Cited
2002
Highly Cited
2002
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
Sprouty (Spry) inhibits signalling by receptor tyrosine kinases; however, the molecular mechanism underlying this function has… Expand
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Highly Cited
2001
Highly Cited
2001
Evidence for Direct Interaction between Sprouty and Cbl*
Sprouty (SPRY) was first identified in a genetic screen in Drosophila as an antagonist of fibroblast and epidermal growth factor… Expand
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