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Protein Sprouty Homolog 2

Known as: SPRY2, Sprouty 2, Spry-2 
Protein sprouty homolog 2 (315 aa, ~35 kDa) is encoded by the human SPRY2 gene. This protein is involved in antagonism of growth factor signaling… 
National Institutes of Health

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Cytoplasmic matrixSPRY2 geneSignal TransductionSignal Transduction Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
MiR-21 enhanced glioma cells resistance to carmustine via decreasing Spry2 expression.
OBJECTIVE Gliomas are accompanied with high mortality owning to their invasive peculiarity and vulnerability to drug resistance… 
2017
2017
Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes
Aims The heart contraction is controlled by the Ca2+-induced Ca2+ release (CICR) between L-type Ca2+ channels and ryanodine… 
2013
2013
Receptor Tyrosine Kinase Ubiquitylation Involves the Dynamic Regulation of Cbl-Spry2 by Intersectin 1 and the Shp2 Tyrosine Phosphatase
ABSTRACT Ubiquitylation of receptor tyrosine kinases (RTKs) regulates their trafficking and lysosomal degradation. The… 
2013
2013
Expression and Functional Role of Sprouty-2 in Breast Morphogenesis
Branching morphogenesis is a mechanism used by many species for organogenesis and tissue maintenance. Receptor tyrosine kinases… 
2012
2012
Initial Report on Differential Expression of Sprouty Proteins 1 and 2 in Human Epithelial Ovarian Cancer Cell Lines
Sprouty (Spry) proteins, modulators of receptor tyrosine kinase signaling pathways, have been shown to be deregulated in a… 
2011
2011
Sprouty 2 Binds ESCRT-II Factor Eap20 and Facilitates HIV-1 Gag Release
ABSTRACT The four ESCRT (endocytic sorting complexes required for transport) complexes (ESCRT-0, -I, -II, and -III) normally… 
2011
2011
The elusive role of the SPRY2 domain in RyR1
The second of three SPRY domains (SPRY2, S1085 V1208) located in the skeletal muscle ryanodine receptor (RyR1) is contained… 
2009
2009
Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis.
Members of the Sprouty family encode novel proteins that are thought to function primarily as intracellular antagonists of the… 
2009
2009
The enhancement of Raf-1 kinase activity by knockdown of Spry2 is associated with high sensitivity to paclitaxel in v-Ha-ras-transformed NIH 3T3 fibroblasts
We previously demonstrated that the downregulation of Raf-1 kinase may contribute to the development of acquired resistance in… 
2007
2007
Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF‐β1 signaling and EGF as well as FGF receptor tyrosine kinase‐ERK pathways in mesenchymal cells
Mammalian Sprouty2 (Spry2) is a key regulator of the receptor tyrosine kinase/ERK signaling pathway and is involved in many… 
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