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Protein Sprouty Homolog 2
Known as:
SPRY2
, Sprouty 2
, Spry-2
Protein sprouty homolog 2 (315 aa, ~35 kDa) is encoded by the human SPRY2 gene. This protein is involved in antagonism of growth factor signaling…
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National Institutes of Health
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Related topics
Related topics
5 relations
Cytoplasmic matrix
SPRY2 gene
Signal Transduction
Signal Transduction Inhibition
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Sprouty2 Inhibition Resolves Inflammation in Periodontal Disease and Creates a Suitable Environment for Periodontal Tissue Regeneration
T. Sanui
,
T. Fukuda
,
+6 authors
F. Nishimura
2017
Corpus ID: 67823169
Introduction: Periodontitis, a bacterial infection affecting periodontal tissues, results in the alveolar bone destruction. In…
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2017
2017
Natural Killer Cell-specific Genes: Klf12 and Spry2
V. Lam
2017
Corpus ID: 190881589
Author(s): Lam, Viola Chi-Man | Advisor(s): Lanier, Lewis L | Abstract: Natural killer (NK) cells are innate lymphocytes that…
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2016
2016
Abstract B28: Mitogen-activated protein kinase-driven Sprouty2 expression mediates resistance to receptor tyrosine kinase-targeted therapeutics in glioblastoma cells
Evan K. Day
,
M. Lazzara
2016
Corpus ID: 76862154
The therapeutic efficacy of inhibitors of oncogenic kinases in glioblastoma multiforme (GBM) has been disappointing to date. In…
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2015
2015
Intraarticular gene transfer of SPRY2 suppresses adjuvant-induced arthritis in rats
Wei Zhang
,
Jingying Zhu
,
Z. Du
,
Jiyun Yu
,
Yuan-geng Xu
,
Fang Wang
Applied Microbiology and Biotechnology
2015
Corpus ID: 253777269
AKT and ERK pathways have been implicated as therapeutic targets for human rheumatoid arthritis (RA), fibroblast-like…
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2015
2015
BRAF inhibitor PLX4720 in two BRAF inhibitor-resistant cells, indicating a positive role for Spry2 in the growth inhibition induced by BRAF inhibitors. On the other hand, long-term treatment with…
Jun‐Ho Ahn
,
B. Han
,
Michael Lee
2015
Corpus ID: 215718955
Gain-of-function mutations in BRAF have been identifi ed in various cancers (Davies et al., 2002). Notably, BRAF somatic…
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2014
2014
[Over-expression of human SPRY2 promotes the proliferation and survival of HEK293T cells].
Jingying Zhu
,
Z. Du
,
+4 authors
Wei Zhang
Xi bao yu fen zi mian yi xue za zhi = Chinese…
2014
Corpus ID: 30100267
OBJECTIVE To construct a recombinant expression vector pDC315/hSPRY2 carrying human SPRY2 (hSPRY2) gene, and transfect the…
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2014
2014
Regulation of Cell Signaling by Mig6 and Sprouty2 in Cancers With Egfr Mutations
A. Walsh
2014
Corpus ID: 81998422
Epidermal growth factor receptor (EGFR) mutation and overexpression promote tumorigenesis in multiple cancers. Understanding the…
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2010
2010
Spry 2 does not directly modulate Raf-1 kinase activity in v-Haras-transformed NIH 3 T 3 fibroblasts
Jun‐Ho Ahn
,
K. Eum
,
Michael Lee
2010
Corpus ID: 18759295
Sprouty (Spry) proteins have previously been suggested as negative regulators of the MAPK pathway through interaction with Raf-1…
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2010
2010
Abstract 2042: Aberrant expression of miR-21 triggers malignancy of human gliomas by disrupting negative feedback regulator, Spry2
Youn-Jae Kim
,
H. Kwak
,
J. B. Park
,
Seung-Hoon Lee
2010
Corpus ID: 87965527
The malignant progression of glioma is accompanied by diffuse infiltration. Recent evidences suggest the significant role of…
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2009
2009
Comparison of Gene Expression between Cumulus Oocyte Complexes and Naked Oocytes by Suppression Subtractive Hybridization in Swine
Z. Xiang
,
J. Z. Zhang
,
Xue Li
,
Hongguang Xie
,
Q. Wang
2009
Corpus ID: 16869342
In the antral follicle phase, several layers of cumulus cells surround the oocyte and play an important support and regulation…
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