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Protein Overexpression

Known as: Overexpression, overexpress 
In biology, to make too many copies of a protein or other substance. Overexpression of certain proteins or other substances may play a role in cancer… 
National Institutes of Health

Related topics

Related topics

3 relations
Gene ExpressionRibosomesmRNA Expression

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Bim Is Elevated in Alzheimer's Disease Neurons and Is Required for β-Amyloid-Induced Neuronal Apoptosis
The molecules that mediate neuron death in Alzheimer's disease (AD) are largely unknown. We report that β-amyloid (Aβ), a death… 
Highly Cited
2006
Highly Cited
2006
Local Targeting of Malignant Gliomas by the Diffusible Peptidic Vector 1,4,7,10-Tetraazacyclododecane-1-Glutaric Acid-4,7,10-Triacetic Acid-Substance P
Purpose: Malignant glial brain tumors consistently overexpress neurokinin type 1 receptors. In classic seed-based brachytherapy… 
Highly Cited
2005
Highly Cited
2005
Treatment with an Amyloid-β Antibody Ameliorates Plaque Load, Learning Deficits, and Hippocampal Long-Term Potentiation in a Mouse Model of Alzheimer's Disease
PDAPP transgenic mice overexpress a mutant form of human amyloid precursor protein under control of the platelet-derived growth… 
Highly Cited
2003
Highly Cited
2003
Increased 99mTc-sestamibi accumulation in normal liver and drug-resistant tumors after the administration of the glycoprotein inhibitor, XR9576.
99mTc-sestamibi, a substrate of the multidrug transporter P-glycoprotein (Pgp), has been used as a functional imaging agent for… 
Highly Cited
2000
Highly Cited
2000
A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines.
The hdm2 protein negatively regulates p53 tumour suppressor activity. Upon binding to p53, hdm2 stimulates p53 degradation and… 
Highly Cited
1999
Highly Cited
1999
The chloroplast small heat shock protein undergoes oxidation-dependent conformational changes and may protect plants from oxidative stress.
The nuclear-encoded chloroplast-localized Hsp21 is an oligomeric heat shock protein (Hsp), belonging to the protein family of… 
Highly Cited
1997
Highly Cited
1997
Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.
Overexpression of Alzheimer amyloid precursor protein (APP) produces dramatically different phenotypes in transgenic mice… 
Highly Cited
1995
Highly Cited
1995
The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.
Recent experimental evidence has focused attention to the role of two molecules, insulin receptor substrate 1 (IRS-1) and… 
Highly Cited
1990
Highly Cited
1990
Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression
By using a retrovirus-derived vector system, we generated derivatives of the human colon cancer cell line HT29 that stably… 
Highly Cited
1988
Highly Cited
1988
Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src
C3H10T1/2 murine fibroblasts overexpressing chicken pp60c-src showed a two- to fivefold enhanced incorporation of [3H]thymidine… 
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