Protein Misfolding Disorders

Eukaryotic cells are partitioned into functionally distinct self-organizing compartments. But while the biogenesis of membrane… (More)

Protein Misfolding Disorders (PMDs) are a group of diseases characterized by the accumulation of abnormally folded proteins… (More)

The autoinflammatory diseases are characterized by seemingly unprovoked episodes of inflammation, without high-titer… (More)

Protein misfolding and aggregation are pathognomic for a number of the most common age-related degenerative diseases. Great… (More)

The accumulation of β-sheet–rich amyloid fibrils or aggregates is a complex, multistep process that is associated with cellular… (More)

Protein misfolding is a common event in living cells. In young and healthy cells, the misfolded protein load is disposed of by… (More)

Newly synthesized proteins in the living cell must go through a folding process to attain their functional structure. To achieve… (More)

Small molecule-mediated protein stabilization inside or outside of the cell is a promising strategy to treat protein misfolding… (More)

Amyloid fibrillization is multistep process involving soluble oligomeric intermediates, including spherical oligomers and… (More)

A range of human degenerative conditions, including Alzheimer's disease, light-chain amyloidosis and the spongiform… (More)