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Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum.
Calreticulin is an ER (endoplasmic reticulum) luminal Ca2+-buffering chaperone. The protein is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. The protein impacts onExpand
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Calreticulin: one protein, one gene, many functions.
The endoplasmic reticulum (ER) plays a critical role in the synthesis and chaperoning of membrane-associated and secreted proteins. The membrane is also an important site of Ca(2+) storage andExpand
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Quality control in the endoplasmic reticulum.
  • M. Michalak
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 1 July 2010
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Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57*
The endoplasmic reticulum is the site of folding, disulfide bond formation, and N-glycosylation of secretory proteins. Correctly folded proteins are exported from the endoplasmic reticulum, whereasExpand
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Modulation of gene expression by calreticulin binding to the glucocorticoid receptor
CALRETICULIN is a multifunctional protein that acts as a major Ca2+-binding (storage) protein in the lumen of the endoplasmic reticulum1. It is also found in the nucleus2, suggesting that it may haveExpand
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Calreticulin: non‐endoplasmic reticulum functions in physiology and disease
Calreticulin (CRT), when localized to the endoplasmic reticulum (ER), has important functions in directing proper conformation of proteins and glycoproteins, as well as in homeostatic control ofExpand
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Characterization of monoclonal antibody to DNA.RNA and its application to immunodetection of hybrids.
Monoclonal antibodies were raised to a DNA.RNA heteropolymer duplex prepared by transcription of phi X174 single-stranded DNA with DNA-dependent RNA polymerase. A monoclonal antibody with the highestExpand
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Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum.
A cDNA clone encoding the high affinity Ca2+-binding protein (HACBP) of rabbit skeletal muscle sarcoplasmic reticulum was isolated and sequenced. The cDNA encoded a protein of 418 amino acids, but aExpand
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Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum.
The endoplasmic reticulum is a centrally located organelle which affects virtually every cellular function. Its unique luminal environment consists of Ca(2+) binding chaperones, which are involved inExpand
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Calcium, a signaling molecule in the endoplasmic reticulum?
For many years now, it has been known that Ca2+ is an important signaling molecule in the cytosol of the cell, but emerging evidence suggests that Ca2+ might also play a signaling role in theExpand
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