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Protein Kinase M

 
National Institutes of Health

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Protein Kinase C

Papers overview

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2015
2015
Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury
The insular cortex (IC) is associated with important functions linked with pain and emotions. According to recent reports, neural… Expand
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Highly Cited
2013
Highly Cited
2013
PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory
Long-term potentiation (LTP), a well-characterized form of synaptic plasticity, has long been postulated as a cellular correlate… Expand
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Highly Cited
2013
Highly Cited
2013
Prkcz null mice show normal learning and memory
Protein kinase M-ζ (PKM-ζ) is a constitutively active form of atypical protein kinase C that is exclusively expressed in the… Expand
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2012
2012
Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory.
A number of recent studies have used pharmacological inhibitors to establish a role for protein kinase Mζ (PKMζ) in synaptic… Expand
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Highly Cited
2011
Highly Cited
2011
Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase Mzeta (PKMzeta).
Activity-dependent synaptic plasticity is widely accepted to be the cellular correlate of learning and memory. It is believed… Expand
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Review
2011
Review
2011
How does PKMζ maintain long-term memory?
Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time… Expand
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2011
2011
Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia.
How the brain maintains long-term memories is one of the major outstanding questions in modern neuroscience. Evidence from… Expand
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Highly Cited
2010
Highly Cited
2010
PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking
The maintenance of long-term memory in hippocampus, neocortex and amygdala requires the persistent action of the atypical protein… Expand
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2009
2009
The atypical protein kinase C in Aplysia can form a protein kinase M by cleavage.
In vertebrates, a brain-specific transcript from the atypical protein kinase C (PKC) zeta gene encodes protein kinase M (PKM… Expand
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2007
2007
Calcium influx through L-type channels generates protein kinase M to induce burst firing of dopamine cells in the rat ventral tegmental area.
Enhanced activity of the dopaminergic system originating in the ventral tegmental area is implicated in addictive and psychiatric… Expand
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