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Protegrin

One of a family of small proteins found in white blood cells in pigs. Protegrins kill certain bacteria, fungi, and viruses by making holes in their… 
National Institutes of Health

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Related topics

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LeukocytesPorcine specieshost defense

Broader (1)

protegrins

Papers overview

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2013
2013
Safety profile of antimicrobial peptides: camel, citropin, protegrin, temporin a and lipopeptide on HaCaT keratinocytes.
Antimicrobial peptides (AMPs) are an essential part of the innate immunity of the skin and mucosal surfaces. They have a broad… 
2008
2008
Short linear cationic antimicrobial peptides: screening, optimizing, and prediction.
The problem of pathogenic antibiotic-resistant bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa is worsening… 
2003
2003
Administration of protegrin peptide IB-367 to prevent endotoxin induced mortality in bile duct ligated rats
Background: Postoperative morbidity in patients with obstructive jaundice remains high because of increased susceptibility to… 
Highly Cited
2002
Highly Cited
2002
Solid-state NMR investigations of peptide-lipid interaction and orientation of a beta-sheet antimicrobial peptide, protegrin.
Protegrin-1 (PG-1) is a broad-spectrum beta-sheet antimicrobial peptide found in porcine leukocytes. The mechanism of action and… 
Review
2002
Review
2002
The Role of Defensins in Lung Biology and Therapy
Innate host defence, involving both cellular and humoral mediators, is a prominent function of the human airways. Cellular… 
Highly Cited
2002
Highly Cited
2002
Antimicrobial Peptides Initiate IL-1β Posttranslational Processing: A Novel Role Beyond Innate Immunity
Human monocytes stimulated with LPS produce large quantities of prointerleukin-1β, but little of this cytokine product is… 
1999
1999
Cathelicidin Gene Expression in Porcine Tissues: Roles in Ontogeny and Tissue Specificity
ABSTRACT Cathelicidins constitute a family of mammalian antimicrobial peptides that are synthesized in the bone marrow as… 
1998
1998
Haemophilus ducreyi Is Susceptible to Protegrin
ABSTRACT Protegrins, potent antimicrobial peptides found in porcine leukocytes, have activity against the sexually transmitted… 
Highly Cited
1997
Highly Cited
1997
Protegrin structure and activity against Neisseria gonorrhoeae
Protegrin 1 (PG-1) is a broad-spectrum antimicrobial peptide that contains 18 amino acid residues (RG GRLCYCRRRFCVCVGR) and has… 
Highly Cited
1996
Highly Cited
1996
Protegrins: structural requirements for inactivating elementary bodies of Chlamydia trachomatis
We tested 20 protegrins against Chlamydia trachomatis serovar L2 (L2/434/Bu). Five of the protegrins had native structures; the… 
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