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The major surface‐metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide‐induced apoptotic killing
Human infection by the vector‐borne protozoan Leishmania is responsible for substantial worldwide morbidity and mortality. The surface‐metalloprotease (leishmanolysin) of Leishmania is a virulenceExpand
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Rapid screening of antibiotic toxicity in an automated microdroplet system.
We report an automated microfluidic platform for 'digitally' screening the composition space of droplets containing cocktails of small molecules and demonstrate the features of this system byExpand
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Effect of Cryogrinding on Chemical Stability of the Sparingly Water-Soluble Drug Furosemide
ABSTRACTPurposeTo investigate the effect of cryogrinding on chemical stability of the diuretic agent furosemide and its mixtures with selected excipients.MethodsFurosemide was ground at liquidExpand
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The hypoxia‐inducible miR‐429 regulates hypoxia‐inducible factor‐1α expression in human endothelial cells through a negative feedback loop
Hypoxia‐inducible factors (HIFs) 1 and 2 are dimeric α/β transcription factors that regulate cellular responses to low oxygen. HIF‐1 is induced first, whereas HIF‐2 is associated with chronicExpand
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Novel properties of antimicrobial peptides.
Endogenous peptide antibiotics are known as evolutionarily old components of innate immunity. Due to interaction with cell membrane these peptides cause permeabilization of the membrane and lysis ofExpand
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Evidence for potential functionality of nuclearly-encoded humanin isoforms.
Humanin (HN) is a recently identified neuroprotective and antiapoptotic peptide derived from a portion of the mitochondrial MT-RNR2 gene. We provide bioinformatic and expression data suggesting theExpand
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Antitumor activity of antimicrobial peptides against U937 histiocytic cell line.
We investigated cytotoxic activity of antimicrobial peptides of different origin (both naturally occurring and synthetic), structure and known mechanisms of action against human histiocytic lymphomaExpand
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Antimicrobial Peptide-induced Apoptotic Death of Leishmania Results from Calcium-de pend ent, Caspase-independent Mitochondrial Toxicity*
α- and θ-defensin-, magainin-, and cathelicidin-type antimicrobial peptides (AMPs) can kill the pathogenic protozoan Leishmania. Comparative studies of a panel of AMPs have defined two distinctExpand
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In Vitro Activity of Aurein 1.2 Alone and in Combination with Antibiotics against Gram-Positive Nosocomial Cocci
ABSTRACT This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci.Expand
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Hydrocarbon Stapled Antimicrobial Peptides
Antimicrobial peptides are promising candidates for anti-infective pharmaceuticals. Unfortunately, because of their low proteolytic and chemical stability, their usage is generally narrowed down toExpand
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