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The major surface‐metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide‐induced apoptotic killing
- Manjusha Kulkarni, W. McMaster, E. Kamysz, W. Kamysz, D. Engman, B. McGwire
- BiologyMolecular microbiology
- 1 December 2006
Results demonstrate leishmanolysin as a virulence factor preventing AMP‐mediated apoptotic killing of Leishmania and demonstrates the potential that AMP evasion plays during host infection by this parasite.
Comparative activities of cecropin A, melittin, and cecropin A–melittin peptide CA(1–7)M(2–9)NH2 against multidrug-resistant nosocomial isolates of Acinetobacter baumannii
Effect of Cryogrinding on Chemical Stability of the Sparingly Water-Soluble Drug Furosemide
- K. Adrjanowicz, K. Kamiński, L. Guzik
- Chemistry, Materials SciencePharmaceutical Research
- 25 June 2011
Cryogenic grinding can activate and accelerate not only structural changes (solid state amorphization) but also chemical decomposition of pharmaceuticals.
Rapid screening of antibiotic toxicity in an automated microdroplet system.
An automated microfluidic platform for 'digitally' screening the composition space of droplets containing cocktails of small molecules and the application of this technology in determining the minimum inhibitory concentration and pair-wise interactions of ampicillin, tetracycline, and chloramphenicol against E. coli is demonstrated.
The hypoxia‐inducible miR‐429 regulates hypoxia‐inducible factor‐1α expression in human endothelial cells through a negative feedback loop
- Sylwia Bartoszewska, Kinga Rochan, Rafał Bartoszewski
- BiologyFASEB journal : official publication of the…
- 1 April 2015
RNA‐sequencing‐based transcriptome analysis indicated that inhibition of miRNA‐429 in HUVECs up‐regulated 209 mRNAs, a number of which regulate angiogenesis, and this regulatory network helps explain the Hif‐1 transition to HIF‐2 during chronic hypoxia in endothelial cells.
Evidence for potential functionality of nuclearly-encoded humanin isoforms.
Novel properties of antimicrobial peptides.
An overview of the general mechanism of action of antimicrobial peptides is presented and some of their additional properties, like antitumour activity, mitogenic activity, role in signal transduction pathways and adaptive immune response are discussed.
Antitumor activity of antimicrobial peptides against U937 histiocytic cell line.
- P. Koszałka, E. Kamysz, Magdalena Wejda, W. Kamysz, J. Bigda
- Biology, ChemistryActa biochimica Polonica
- 14 March 2011
The experiments have shown that cytotoxic activity is not limited to some specific molecular structure of a peptide, but rather to the length of the peptide chain as it is likely to affect the efficiency of the tumor cell membrane disruption and interaction with LPS.
The antimicrobial peptide Tachyplesin III coated alone and in combination with intraperitoneal piperacillin-tazobactam prevents ureteral stent Pseudomonas infection in a rat subcutaneous pouch model
Pretreatment with the protegrin IB-367 affects Gram-positive biofilm and enhances the therapeutic efficacy of linezolid in animal models of central venous catheter infection.
- R. Ghiselli, A. Giacometti, V. Saba
- Medicine, BiologyJPEN. Journal of parenteral and enteral nutrition
- 1 November 2007
IB-367 has potential as an adjunctive agent to LZD in the treatment of Gram-positive biofilm infections such as CVC infections and in vivo studies showed that when CVCs were pretreated with IB-367, Gram- positive biofilm bacterial load was decreased to 10(1) CFU/mL and bacteremia was not detected.