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- Publications
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The major surface‐metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide‐induced apoptotic killing
- M. Kulkarni, W. McMaster, Elżbieta Kamysz, W. Kamysz, D. Engman, B. Mcgwire
- Biology, Medicine
- Molecular microbiology
- 1 December 2006
Human infection by the vector‐borne protozoan Leishmania is responsible for substantial worldwide morbidity and mortality. The surface‐metalloprotease (leishmanolysin) of Leishmania is a virulence… Expand
Rapid screening of antibiotic toxicity in an automated microdroplet system.
- Krzysztof Churski, T. Kaminski, +4 authors P. Garstecki
- Chemistry, Medicine
- Lab on a chip
- 3 April 2012
We report an automated microfluidic platform for 'digitally' screening the composition space of droplets containing cocktails of small molecules and demonstrate the features of this system by… Expand
Effect of Cryogrinding on Chemical Stability of the Sparingly Water-Soluble Drug Furosemide
- K. Adrjanowicz, K. Kamiński, +8 authors L. Guzik
- Chemistry, Medicine
- Pharmaceutical Research
- 25 June 2011
ABSTRACTPurposeTo investigate the effect of cryogrinding on chemical stability of the diuretic agent furosemide and its mixtures with selected excipients.MethodsFurosemide was ground at liquid… Expand
The hypoxia‐inducible miR‐429 regulates hypoxia‐inducible factor‐1α expression in human endothelial cells through a negative feedback loop
- Sylwia Bartoszewska, Kinga Rochan, +4 authors Rafal Bartoszewski
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 April 2015
Hypoxia‐inducible factors (HIFs) 1 and 2 are dimeric α/β transcription factors that regulate cellular responses to low oxygen. HIF‐1 is induced first, whereas HIF‐2 is associated with chronic… Expand
Novel properties of antimicrobial peptides.
- W. Kamysz, M. Okrój, J. Łukasiak
- Biology, Medicine
- Acta biochimica Polonica
- 2003
Endogenous peptide antibiotics are known as evolutionarily old components of innate immunity. Due to interaction with cell membrane these peptides cause permeabilization of the membrane and lysis of… Expand
Evidence for potential functionality of nuclearly-encoded humanin isoforms.
- M. Bodzioch, K. Lapicka-Bodzioch, B. Zapała, W. Kamysz, B. Kieć-Wilk, A. Dembińska-kieć
- Biology, Medicine
- Genomics
- 1 October 2009
Humanin (HN) is a recently identified neuroprotective and antiapoptotic peptide derived from a portion of the mitochondrial MT-RNR2 gene. We provide bioinformatic and expression data suggesting the… Expand
Antitumor activity of antimicrobial peptides against U937 histiocytic cell line.
- P. Koszałka, Elżbieta Kamysz, Magdalena Wejda, W. Kamysz, J. Bigda
- Biology, Medicine
- Acta biochimica Polonica
- 14 March 2011
We investigated cytotoxic activity of antimicrobial peptides of different origin (both naturally occurring and synthetic), structure and known mechanisms of action against human histiocytic lymphoma… Expand
Antimicrobial Peptide-induced Apoptotic Death of Leishmania Results from Calcium-de pend ent, Caspase-independent Mitochondrial Toxicity*
- M. Kulkarni, W. McMaster, W. Kamysz, B. Mcgwire
- Biology, Medicine
- The Journal of Biological Chemistry
- 8 April 2009
α- and θ-defensin-, magainin-, and cathelicidin-type antimicrobial peptides (AMPs) can kill the pathogenic protozoan Leishmania. Comparative studies of a panel of AMPs have defined two distinct… Expand
In Vitro Activity of Aurein 1.2 Alone and in Combination with Antibiotics against Gram-Positive Nosocomial Cocci
- A. Giacometti, O. Cirioni, +6 authors G. Scalise
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 12 January 2007
ABSTRACT This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci.… Expand
Hydrocarbon Stapled Antimicrobial Peptides
- Dorian Migoń, Damian Neubauer, W. Kamysz
- Chemistry, Medicine
- The Protein Journal
- 12 January 2018
Antimicrobial peptides are promising candidates for anti-infective pharmaceuticals. Unfortunately, because of their low proteolytic and chemical stability, their usage is generally narrowed down to… Expand