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Protac

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Proteolysis‐targeting chimeras in drug development: A safety perspective
Proteolysis‐targeting chimeras are a new drug modality that exploits the endogenous ubiquitin proteasome system to degrade a… 
Highly Cited
2020
Highly Cited
2020
A caged E3 ligase ligand for PROTAC-mediated protein degradation with light.
With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was… 
2020
2020
PROTAC Compounds Targeting α-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer's and Parkinson's Diseases.
Title. Proteolysis targeting chimeric (PROTAC) compound with E3 ubiquitin ligase binding activity and targeting alphasynuclein… 
Highly Cited
2019
Highly Cited
2019
Simple Structural Modifications Converting a Bona Fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders.
Inducing protein degradation by proteolysis targeting chimeras (PROTACs) has gained tremendous momentum for its promise to… 
Highly Cited
2018
Highly Cited
2018
Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity.
Highly Cited
2016
Highly Cited
2016
Novel BET protein Proteolysis Targeting Chimera (BET-PROTAC) exerts superior lethal activity than Bromodomain Inhibitor (BETi) against post-myeloproliferative Neoplasm (MPN) Secondary (s) AML Cells
The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin… 
Highly Cited
2014
Highly Cited
2014
Procoagulant imbalance in patients with non-alcoholic fatty liver disease.
Highly Cited
2013
Highly Cited
2013
Evidence that low protein C contributes to the procoagulant imbalance in cirrhosis.
Highly Cited
2010
Highly Cited
2010
Detection of the imbalance of procoagulant versus anticoagulant factors in cirrhosis by a simple laboratory method
Patients with cirrhosis possess an imbalance in procoagulant versus anticoagulant activity due to increased factor VIII and… 
Highly Cited
2010
Highly Cited
2010
Enhanced thrombin generation in patients with cirrhosis‐induced coagulopathy
Summary.  Background: Prothrombin time (PT) and the international normalized ratio (INR) are still routinely measured in patients… 
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