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Protac

National Institutes of Health

Papers overview

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2015
2015
Thrombin generation and coagulation factor content of thawed plasma and platelet concentrates
We assessed the haemostatic capacity of thawed plasma produced after ambient storage of whole blood for 24 h (RTFP24), and the… 
2012
2012
Development and application of an automated chromogenic thrombin generation assay that is sensitive to defects in the protein C pathway.
2010
2010
Abnormal Protac-induced coagulation inhibition chromogenic assay results are associated with an increased risk of recurrent venous thromboembolism
Evaluation of the risk of recurrent venous thromboembolism (VTE) is required to determine the optimal duration of secondary… 
2000
2000
Screening for abnormalities of the protein C anticoagulant pathway using the ProC Global assay. Results of a European multicenter evaluation
ProC Global is a new global clotting assay designed to evaluate the functionality of the protein C anticoagulant pathway. It is… 
2000
2000
Comparative effects of the human protein C activator, Protac, on the activated partial thromboplastin clotting times of plasmas, with special reference to the dog.
The commercial snake venom extract, Protac, is a specific activator of the anticoagulant zymogen, protein C (PC) in human plasma… 
1998
1998
ProC global: a new assay to evaluate the functionality of the protein C anticoagulant pathway preliminary results in 223 consecutive patients with a history of venous thromboembolism
1997
1997
A Protac®-based screening test for activated protein C-resistant factor Va and other defects of the protein C anticoagulant pathway
We have standardized a simple screening test for abnormalities of the protein C anticoagulant system. The test is basically a… 
1996
1996
The Gla26 Residue of Protein C Is Required for the Binding of Protein C to Thrombomodulin and Endothelial Cell Protein C Receptor, but not to Protein S and Factor Va
Summary A functionally defective protein C (PC)-Mie, detected in the plasma of a patient with hereditary thrombophilia, has Lys… 
1994
1994
Plasma protein c activity is enhanced by arsenic but inhibited by fluorescent humic acid associated with blackfoot disease
Blackfoot disease is a peripheral vascular disease causally related to the fluorescent humic acid found in the drinking water of… 
1988
1988
Practical application of the protein C activator Protac from Agkistrodon contortrix venom.
The protein C activator Protac from A. contortrix venom is being investigated as a potential antithrombotic agent and as a tool… 
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