Proopiomelanocortin Deficiency

Except in rare cases, obesity tends to be a consequence of both an unhealthy lifestyle and a genetic susceptibility to gain… Expand

Despite being in the age of information technology, with a wealth of molecular data at our fingertips, relatively simple clinical… Expand

Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia… Expand

Proopiomelanocortin (POMC) has been at the forefront of molecular endocrinology for the past 60 years, and the concepts derived… Expand

INTRODUCTION Common obesity is a multi-factorial trait, contributed by the "obesogenic" environment of caloric abundance and… Expand

The mature adrenal cortex is dependent upon proopiomelanocortin (POMC)-derived peptides for the maintenance of its size… Expand

The symptoms of severe early-onset obesity, adrenal insufficiency, and red hair define the proopiomelanocortin (POMC) deficiency… Expand